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lung cancer brain metastasis

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By Targets:	Akt (1) Apoptosis (1) EGFR (2) ERK (1) Fluorescent Dye (1) MMP (1) p38 MAPK (1) Reference Standards (2) Transmembrane Glycoprotein (1) TRP Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (1) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

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Fluorescent Dyes

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Natural
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Click Chemistry

Targets Recommended: BCRP

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dye MMP	Cancer
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

HY-139300

Epitinib HMPL-813	EGFR	Cancer
Epitinib (HMPL-813) is a selective, orally active, blood-brain barrier-permeable EGFR tyrosine kinase inhibitor. Epitinib is applicable to research on EGFR ^T790M-positive non-small cell lung cancer with brain metastasis and advanced solid tumors .

HY-P99658A

Imaprelimab (powder)	Transmembrane Glycoprotein	Cardiovascular Disease Neurological Disease Cancer
Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer .

HY-N18209

4-Hydroxy-3-butylphthalide	p38 MAPK	Cancer
4-Hydroxy-3-butylphthalide is a Phthalide (HY-W015820) derivative found in the rhizome of Ligusticum ChuanXiong Hort. 4-Hydroxy-3-butylphthalide binds core targets linked to lung cancer brain metastasis, such as BDNF, FOS, and MAPK14. 4-Hydroxy-3-butylphthalide can be used for the research of lung cancer brain metastasis .

HY-109061R

Lazertinib (Standard) YH25448 (Standard); GNS-1480 (Standard)	Apoptosis Akt TRP Channel EGFR ERK Reference Standards	Infection Neurological Disease Metabolic Disease Cancer
Lazertinib (Standard) is the analytical standard of Lazertinib (HY-109061). This product is intended for research and analytical applications. Lazertinib (YH25448) is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine K_inase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib can be used in the study of non-small cell lung cancer .

HY-109061BR

Lazertinib mesylate (Standard) YH25448 mesylate (Standard); GNS-1480 mesylate (Standard)	Reference Standards	Cancer
Lazertinib mesylate (Standard) is the analytical standard of Lazertinib (mesylate) (HY-109061B). This product is intended for research and analytical applications. Lazertinib (YH25448) mesylate is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine K_inase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib mesylate inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib mesylate can be used in the study of non-small cell lung cancer .

Cat. No.	상품명	Type

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dyes
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

MOCAc-PLGL(Dpa)AR

Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

Fluorescent Dyes

MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

Cat. No.	상품명	Target	Research Area	Image

HY-P99658A

Imaprelimab (powder)	Transmembrane Glycoprotein	Cardiovascular Disease Neurological Disease Cancer
Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer .

4-Hydroxy-3-butylphthalide	Structural Classification Monophenols Phenols Dicerothamnus rhinocerotis Umbelliferae Plants Source Classification	p38 MAPK
4-Hydroxy-3-butylphthalide is a Phthalide (HY-W015820) derivative found in the rhizome of Ligusticum ChuanXiong Hort. 4-Hydroxy-3-butylphthalide binds core targets linked to lung cancer brain metastasis, such as BDNF, FOS, and MAPK14. 4-Hydroxy-3-butylphthalide can be used for the research of lung cancer brain metastasis .

Cat. No.	상품명		Classification

HY-139300

Epitinib HMPL-813		Alkynes
Epitinib (HMPL-813) is a selective, orally active, blood-brain barrier-permeable EGFR tyrosine kinase inhibitor. Epitinib is applicable to research on EGFR ^T790M-positive non-small cell lung cancer with brain metastasis and advanced solid tumors .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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lung cancer brain metastasis

Inhibitors & Agonists

Fluorescent Dyes

Inhibitory Antibodies

NaturalProducts

Click Chemistry

Natural
Products