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metabolite of Eicosapentaenoic Acid

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Art. -Nr. Produktname Target Forschungsgebiete Chemical Structure
  • HY-113040A
    (17R,18S)-Epoxyeicosatetraenoic acid

    17(R),18(S)-EETeTr

    		 Calcium Channel Cardiovascular Disease
    (17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia .
    (17R,18S)-Epoxyeicosatetraenoic acid
  • HY-175098
    (±)14(15)-DiHETE

    		Drug Metabolite Metabolic Disease
    (±)14(15)-DiHETE, an oxylipin, is a metabolite of Eicosapentaenoic Acid (HY-B0660). Eicosapentaenoic Acid is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA) .
    (±)14(15)-DiHETE
  • HY-175079
    (±)17(18)-DiHETE

    		Drug Metabolite Metabolic Disease
    (±)17(18)-DiHETE is an oxidized lipid and a metabolite of Eicosapentaenoic Acid (HY-B0660), an orally active omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA) .
    (±)17(18)-DiHETE
  • HY-113484
    Leukotriene B5

    LTB5

    		 Leukotriene Receptor Cancer
    Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4.
    Leukotriene B5
  • HY-130319
    9(S)-HEPE

    		Drug Metabolite Metabolic Disease
    9(S)-HEPE, a hydroxy fatty acid, is a metabolite of Eicosapentaenoic acid .
    9(S)-HEPE
  • HY-157910
    (±)17(18)-EpETE methyl ester

    		Drug Metabolite Metabolic Disease
    (±)17(18)-EpETE methyl ester is an analog of the eicosapentaenoic acid (EPA) metabolite (±)17(18)-EpETE .
    (±)17(18)-EpETE methyl ester
  • HY-121888
    20-HEPE

    		PPAR Metabolic Disease
    20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.
    20-HEPE
  • HY-113513
    5-HEPE

    		Others Cancer
    5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.
    5-HEPE
  • HY-113040B
    (±)-(17S,18R)-Epoxyeicosatetraenoic acid

    (±)-17(S),18(R)-EETeTr

    		 Drug Isomer Others
    (±)-(17S,18R)-Epoxyeicosatetraenoic acid ((±)-17 (S),18 (R)-EETeTr) is one of the constituent enantiomers of (±) 17 (18)-EpETE. (±) 17 (18)-EpETE is an active metabolite of the ω-3 fatty acid eicosapentaenoic acid, and also an agonist of sphingosine-1-phosphate receptor 1 (S1P1) .
    (±)-(17S,18R)-Epoxyeicosatetraenoic acid

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