metallothionein

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) Cytochrome P450 (1) Drug Derivative (2) Drug Intermediate (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fluorescent Dye (2) Herbicide (1) HSV (1) PROTACs (1) Proteasome (1) TRP Channel (1)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124171

Zinquin ethyl ester 1 Publications Verification	Fluorescent Dye Drug Derivative	Others
Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn ²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm) .

HY-B0658A

Zinc acetate dihydrate, ACS, 98% Zinc(II) acetate dihydrate, ACS, 98%	Biochemical Assay Reagents	Others
Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Endogenous Metabolite	Others
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-168969

AA-BR-157	PROTACs	Neurological Disease Cancer
AA-BR-157 is a metallothionein 2A (MT2A) PROTAC degrader, DC₅₀ is 200 nM (MT2A overexpressed in MDA-MB-231 cells). AA-BR-157 increases intracellular zinc levels, downregulates DIAPH3, disrupts cytoskeleton remodeling, and reduces the migration and invasion abilities of cancer cells. AA-BR-157 can be used for research on triple-negative breast cancer and glioblastoma .

HY-W101299

*N-Acetyl-D-allo-isoleucine*	Amino Acid Derivatives	Metabolic Disease
N-Acetyl-D-allo-isoleucine is an amino acid derivative. N-Acetyl-D-allo-isoleucine is promising for research of amino acid metabolism, such as abnormal isoleucine metabolism .

HY-W714225

Sodium methylarsonate Monosodium methylarsonate	Environmental Pollutants Herbicide	Others
Sodium methylarsonate (Monosodium methylarsonate) is an organoarsenic compound with environmental toxicity that can be used as a herbicide to control weeds. Sodium methylarsonate interferes with plant metabolic processes, particularly by hindering photosynthesis and protein synthesis, ultimately leading to plant death. Additionally, sodium methylarsonate can induce the production of metallothioneins (MTs) in fish .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-P11715

Abz-GFDPFRQ-EDDnp	Fluorescent Dye	Neurological Disease
Abz-GFDPFRQ-EDDnp is a fluorogenic substrate for metallothionein oligopeptidase (λ_ex=320 nm, λ_em=420 nm). Abz-GFDPFRQ-EDDnp is used to determine the enzymatic activity of metallothionein oligopeptidase in tissue extracts and for research on temporal lobe epilepsy .

HY-119578

Imiprothrin	Cytochrome P450	Cancer
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

HY-P4613

*Fmoc-D-allo-Thr-OH*	Drug Derivative Drug Intermediate	Others
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .

HY-P11022

TL-119 A-3302-B	Endogenous Metabolite HSV TRP Channel	Infection Cancer
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .

Cat. No.	Product Name	Type

HY-124171

Zinquin ethyl ester 1 Publications Verification	Fluorescent Dyes
Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn ²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm) .

Cat. No.	Product Name	Type

HY-B0658A

Zinc acetate dihydrate, ACS, 98% Zinc(II) acetate dihydrate, ACS, 98%	Biochemical Assay Reagents
Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

Zinc acetate dihydrate, ACS, 98%

Zinc(II) acetate dihydrate, ACS, 98%

Biochemical Assay Reagents

Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

Cat. No.	Product Name	Target	Research Area

HY-W101299

*N-Acetyl-D-allo-isoleucine*	Amino Acid Derivatives	Metabolic Disease
N-Acetyl-D-allo-isoleucine is an amino acid derivative. N-Acetyl-D-allo-isoleucine is promising for research of amino acid metabolism, such as abnormal isoleucine metabolism .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-P11715

Abz-GFDPFRQ-EDDnp	Fluorescent Dye	Neurological Disease
Abz-GFDPFRQ-EDDnp is a fluorogenic substrate for metallothionein oligopeptidase (λ_ex=320 nm, λ_em=420 nm). Abz-GFDPFRQ-EDDnp is used to determine the enzymatic activity of metallothionein oligopeptidase in tissue extracts and for research on temporal lobe epilepsy .

HY-P4613

*Fmoc-D-allo-Thr-OH*	Drug Derivative Drug Intermediate	Others
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .

HY-P11022

TL-119 A-3302-B	Endogenous Metabolite HSV TRP Channel	Infection Cancer
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P706009

	Mt3 Protein, Rat (His-SUMO) Mt3; metallothionein-3; MT-3; Growth inhibitory factor (GIF); metallothionein-III (MT-III)	Rat	E. coli

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Cat. No.	Product Name		Classification

HY-119578

Imiprothrin		Alkynes
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

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metallothionein

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Biochemical Assay Reagents

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