Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
metallothionein
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "metallothionein" in MCE Product Catalog:
2
2 Cited Publications
1
1 Cited Publications
Cat. No.: HY-13545
CAS No.: 251579-55-2
Target:
Research Areas:
Synonyms: MDCG sodium
Research Areas:
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .
Cat. No.: HY-168969
Target:
Research Areas:
AA-BR-157 is a metallothionein 2A (MT2A) PROTAC degrader, DC50 is 200 nM (MT2A overexpressed in MDA-MB-231 cells). AA-BR-157 increases intracellular zinc levels, downregulates DIAPH3, disrupts cytoskeleton remodeling, and reduces the migration and invasion abilities of cancer cells. AA-BR-157 can be used for research on triple-negative breast cancer and glioblastoma .
Cat. No.: HY-W101299
CAS No.: 54831-20-8
Target:
Research Areas:
Cat. No.: HY-W714225
CAS No.: 2163-80-6
Synonyms: Monosodium methylarsonate
Target:
Research Areas:
Sodium methylarsonate (Monosodium methylarsonate) is an organoarsenic compound with environmental toxicity that can be used as a herbicide to control weeds. Sodium methylarsonate interferes with plant metabolic processes, particularly by hindering photosynthesis and protein synthesis, ultimately leading to plant death. Additionally, sodium methylarsonate can induce the production of metallothioneins (MTs) in fish .
Cat. No.: HY-P4910
CAS No.: 1622872-91-6
Target:
Research Areas:
Cat. No.: HY-P2120
CAS No.: 79438-64-5
Cat. No.: HY-P3119
CAS No.: 194660-14-5
Synonyms: Desotamide A
Target:
Research Areas:
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).
Cat. No.: HY-P706009
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MT3; GIFB; metallothionein 3; metallothionein; GIF; MT-III; metallothionein-III; ZnMT3; metallothionein-3; GRIF; metallothionein 3 (Growth Inhibitory Factor (Neurotrophic)); MT-3; Growth Inhibitory Factor
Species:
Rat
Source:
E. coli
Cat. No.: HY-184233
Target:
Research Areas:
C9S is an As (III)-PROTAC and arsenic-binding protein PROTAC degrader. C9S promotes the ubiquitination and degradation of arsenic-binding proteins such as Glutathione reductase. C9S binds to metallothionein. C9S exhibits anticancer activity against lung cancer. C9S can be used in lung cancer-related research .
Cat. No.: HY-P11715
CAS No.: 960607-97-0
Target:
Research Areas:
Cat. No.: HY-187678
CAS No.: 3024011-79-5
Research Areas:
NCGC-023 is a LATS1/2 inhibitor. NCGC-023 selectively inhibits LATS1/2, an upstream regulator of Yap in the Hippo signaling pathway, increases the expression of active Yap protein, activates Yap-dependent signaling pathways, triggers non-Yap-dependent metallothionein-mediated heavy metal responses, and upregulates IL-33-related regenerative responses. NCGC-023 can be used in studies related to gastrointestinal acute radiation syndrome (GI-ARS) .
Cat. No.: HY-119578
CAS No.: 72963-72-5
Target:
Research Areas:
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .
Cat. No.: HY-P4613
CAS No.: 130674-54-3
Target:
Research Areas:
Cat. No.: HY-P11022
CAS No.: 55599-68-3
Synonyms: A-3302-B
Target:
Cat. No.: HY-P3303
CAS No.: 146556-41-4
PF1070A is a Pf HDAC1 inhibitor with an IC50 of 0.0011 μM. By inhibiting histone deacetylase (HDAC) activity, PF1070A induces histone H4 hyperacetylation and chromatin remodeling, arrests cell cycle progression prior to nuclear division, and exhibits antimalarial activity against multidrug-resistant Plasmodium falciparum strains with high selectivity. PF1070A is suitable for use in malaria research .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
