TL-119  (Synonyms: A-3302-B)

TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer^[1][2].

TL-119 (0.4-100 µM; 2 h) specifically inhibits HSV-2 infection in Vero cells, with an EC₅₀ of 14.22 µM, including acyclovir-resistant HSV-2 strains^[1].
TL-119 (0.4-100 µM) reduces the titer of HSV-2 in Vero cells, with an EC₅₀ of 11.31 µM^[1].
TL-119 (10-100 μM; 48 h) reduces the viability of AGS and Caco2 cells in a concentration-dependent manner, but exerts no effect on the viability of A549 cells after 48 h of treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

690.79

C₃₆H₄₆N₆O₈

55599-68-3

Ac-{d-Phe}-{d-Leu}-Phe-{d-allo-Thr}-Val-Ala-{Z-Dhb} (lactone bridge:Thr4-Dhb7)

Ac-{d-Phe}-{d-Leu}-F{d-allo-Thr}VA-{Z-Dhb} (lactone bridge:Thr4-Dhb7)

O=C(N[C@H](C(N[C@H](C(N/C(C(O[C@@H]1C)=O)=C\C)=O)C)=O)C(C)C)[C@@H]1NC([C@@H](NC([C@H](NC(C)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O

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• [1]. Sureram S, et al. The Peptide A-3302-B Isolated from a Marine Bacterium Micromonospora sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells. Int J Mol Sci. 2022 Jan 15;23(2):947.

  [2]. Le TC, et al. Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression. ACS Omega. 2022;7(2):1722-1732. Published 2022 Jan 3.