TL-119
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 55599-68-3
- Formula: C36H46N6O8
- Molecular Weight:690.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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HSV-2 |
TRPV1 |
Microbial Metabolite |
TL-119 (0.4-100 µM; 2 h) specifically inhibits HSV-2 infection in Vero cells, with an EC50 of 14.22 µM, including acyclovir-resistant HSV-2 strains[1].
TL-119 (0.4-100 µM) reduces the titer of HSV-2 in Vero cells, with an EC50 of 11.31 µM[1].
TL-119 (10-100 μM; 48 h) reduces the viability of AGS and Caco2 cells in a concentration-dependent manner, but exerts no effect on the viability of A549 cells after 48 h of treatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells
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Concentration:79.64 µM
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Incubation Time:pre-incubation, co-incubation, and post-infection treatment; extract collected at 4 hpi, 16 hpi
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Result:Did not inhibit the expression of ICP4, ICP8, or gD HSV-2 proteins at 4 hpi.
Did not inhibit the expression of ICP4, ICP8, or gD HSV-2 proteins at 16 hpi.
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Cell Line:AGS (gastric cancer), A549 (lung cancer), Caco2 (colorectal cancer)
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Concentration:10 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:48 h
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Result:Did not affect AGS cell viability at 10, 25, or 50 μM.
Caused a significant decrease in AGS cell viability at 100 μM.
Did not affect A549 cell viability at 10, 25, 50, or 100 μM.
Did not affect Caco2 cell viability at 10 or 25 μM.
Caused significant decreases in Caco2 cell viability at 50 and 100 μM.
Chemical Information
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CAS No. 55599-68-3
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Molecular Weight 690.79
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Formula C36H46N6O8
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SMILES
O=C(N[C@H](C(N[C@H](C(N/C(C(O[C@@H]1C)=O)=C\C)=O)C)=O)C(C)C)[C@@H]1NC([C@@H](NC([C@H](NC(C)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O
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Synonyms
A-3302-B
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Sequence
Ac-{d-Phe}-{d-Leu}-Phe-{d-allo-Thr}-Val-Ala-{Z-Dhb} (lactone bridge:Thr4-Dhb7)
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Sequence Shortening
Ac-{d-Phe}-{d-Leu}-F{d-allo-Thr}VA-{Z-Dhb} (lactone bridge:Thr4-Dhb7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sureram S, et al. The Peptide A-3302-B Isolated from a Marine Bacterium Micromonospora sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells. Int J Mol Sci. 2022 Jan 15;23(2):947. [Content Brief]
[2]. Le TC, et al. Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression. ACS Omega. 2022;7(2):1722-1732. Published 2022 Jan 3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TL-119 Related Classifications
HY-P11022 Related Classifications
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