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Isoforms Recommended: NUAK2
Results for "

nuak2

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15802
    WZ4003
    5+ Cited Publications

    		 AMPK Cancer
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
    WZ4003
  • HY-12334
    HTH-01-015
    1 Publications Verification

    		 AMPK Cancer
    HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
    HTH-01-015
  • HY-156397
    HTH-02-006

    		AMPK YAP Cancer
    HTH-02-006 is a NUAK2 inhibitor, with an IC50 value of 126 nM. HTH-02-006 inhibits NUAK2-mediated signaling by reducing phosphorylation of its substrate MYPT1 at S445 and downstream MLC. HTH-02-006 shows growth inhibitory efficacy in YAP-high cancer cells (HuCCT-1, SNU475). HTH-02-006 significantly suppresses YAP-induced hepatomegaly (reduced liver/body weight ratio) in TetO-YAP S127A transgenic mice and demonstrates significant anti-tumor efficacy in mice bearing HMVP2 prostate cancer allografts. HTH-02-006 can be used for the study of liver cancer and prostate cancer [2].
    HTH-02-006
  • HY-162708
    KHKI-01128

    		AMPK Cancer
    KHKI-01128 is a NUAK2 inhibitor, with an IC50 of 0.024 μM. KHKI-01128 exhibits potent anticancer activity against SW480 colorectal cancer cells .
    KHKI-01128
  • HY-162709
    KHKI-01215

    		Apoptosis YAP Cancer
    KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway .
    KHKI-01215
  • HY-170360
    UCB9386

    		AMPK JAK Cancer
    UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM .
    UCB9386
  • HY-E70851
    Nuak2 Recombinant Human Active Protein Kinase

    		AMPK Cancer
    NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions .
    Nuak2 Recombinant Human Active Protein Kinase
  • HY-RS09649
    Nuak2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nuak2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nuak2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nuak2 Rat Pre-designed siRNA Set A
    Nuak2 Rat Pre-designed siRNA Set A
  • HY-RS09647
    NUAK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NUAK2 Human Pre-designed siRNA Set A contains three designed siRNAs for NUAK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NUAK2 Human Pre-designed siRNA Set A
    NUAK2 Human Pre-designed siRNA Set A
  • HY-RS09648
    Nuak2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nuak2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nuak2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nuak2 Mouse Pre-designed siRNA Set A
    Nuak2 Mouse Pre-designed siRNA Set A
  • HY-E70802
    Biotin-Nuak2 Recombinant Human Active Protein Kinase

    		AMPK Cancer
    NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Biotin-Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions, and is biotinylated .
    Biotin-Nuak2 Recombinant Human Active Protein Kinase
  • HY-182743
    OICR19451

    		AMPK MARK YAP Cancer
    OICR19451 is an orally active dual NUAK1/NUAK2 and MARK2/MARK3 kinase inhibitor, with IC50 values of 12 nM and 10 nM against NUAK1 and NUAK2, and 101 nM and 124 nM against MARK2 and MARK3, respectively. OICR19451 modulates the Hippo signaling pathway, increases the phosphorylation level of YAP, enhances the cytoplasmic localization of YAP/TAZ, and inhibits the expression of oncogenes. OICR19451 inhibits cancer cell growth, reduces metastasis, promotes tumor capsule formation, and improves mouse survival in an orthotopic breast cancer model. OICR19451 can be used for research related to triple-negative breast cancer .
    OICR19451
  • HY-182361
    NUAK1-IN-3

    		AMPK JAK Cadherin Cancer
    NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer .
    NUAK1-IN-3

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