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organophosphorus inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Cannabinoid Receptor (1) Carboxylesterase (CES) (1) Cholinesterase (ChE) (9) Drug Metabolite (1) Endogenous Metabolite (3) Environmental Pollutants (3) Estrogen Receptor/ERR (1) FAAH (1) Fungal (3) Insecticide (4) Isotope-Labeled Compounds (3) Parasite (3) Reference Standards (5) Thrombin (1)
By Research Areas:	Cancer (1) Infection (8) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1881

Pirimiphos-methyl 1 Publications Verification	Environmental Pollutants Insecticide Parasite Cholinesterase (ChE)	Infection
Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains .

HY-B2053

Tolclofos-methyl	Fungal	Infection
Tolclofos-methyl is an organophosphorus fungicide. Tolclofos-methyl undergoes photoinduced oxidative degradation to form oxo-analog derivatives. Tolclofos-methyl inhibits spore division in fungi and oomycetes, induces cytoplasmic leakage, and interferes with flagellar movement. Tolclofos-methyl is rapidly metabolized and excreted in rodents. Tolclofos-methyl can be used in studies related to fungal infections .

HY-B1863

Iprobenfos	Environmental Pollutants Cholinesterase (ChE) Fungal	Infection
Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-118165

Phenthoate 2 Publications Verification	Environmental Pollutants Cholinesterase (ChE)	Neurological Disease
Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor .

HY-126199

Tetrachlorvinphos	Endogenous Metabolite	Others
Tetrachlorvinphos is an organophosphorus pesticide that has the activity of inhibiting cholinesterase. Tetrachlorvinphos is used as a pesticide, mainly for the control of pests. Tetrachlorvinphos has low toxicity to mammals .

HY-W783157

Heterophos Heterofos	Insecticide Cholinesterase (ChE)	Infection
Heterophos (Heterofos) is an organophosphorus insecticide and an AChE inhibitor. Heterophos inhibits AChE's function of decomposing acetylcholine, causing disorder of insect nerve conduction and exerting insecticidal effects .

HY-123120

SA-152	Thrombin	Others
SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin .

HY-148909

Isopropyl dodec-11-enylfluorophosphonate IDEFP	Cannabinoid Receptor FAAH	Neurological Disease
Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester that antagonizes the central cannabinoid receptor (CB1) and inhibits FAAH with similar potencies (IC₅₀ = 2 nM) .

HY-118165S

Phenthoate-d6	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Phenthoate-d₆ is deuterium labeled Phenthoate. Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor .

HY-118165R

Phenthoate (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Phenthoate (Standard) is the analytical standard of Phenthoate. This product is intended for research and analytical applications. Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor .

HY-126199R

Tetrachlorvinphos (Standard)	Endogenous Metabolite Reference Standards	Others
Tetrachlorvinphos (Standard) is the analytical standard of Tetrachlorvinphos. This product is intended for research and analytical applications. Tetrachlorvinphos is an organophosphorus pesticide that has the activity of inhibiting cholinesterase. Tetrachlorvinphos is used as a pesticide, mainly for the control of pests. Tetrachlorvinphos has low toxicity to mammals .

HY-126199S

(Z)-Tetrachlorvinphos-d6	Isotope-Labeled Compounds Endogenous Metabolite	Others
(Z)-Tetrachlorvinphos-d₆ is the deuterium labeled Tetrachlorvinphos (HY-126199). Tetrachlorvinphos is an organophosphorus pesticide that has the activity of inhibiting cholinesterase. Tetrachlorvinphos is used as a pesticide, mainly for the control of pests. Tetrachlorvinphos has low toxicity to mammals .

HY-B1881S

Pirimiphos-methyl-d6	Isotope-Labeled Compounds Insecticide Cholinesterase (ChE) Parasite	Infection
Pirimiphos-methyl-d₆ is the deuterium labeled Pirimiphos-methyl (HY-B1881) . Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains .

HY-B1863R

Iprobenfos (Standard)	Reference Standards Fungal Cholinesterase (ChE)	Infection
Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-B1881R

Pirimiphos-methyl (Standard)	Reference Standards Insecticide Cholinesterase (ChE) Parasite	Infection
Pirimiphos-methyl (Standard) is the analytical standard of Pirimiphos-methyl (HY-B1881). This product is intended for research and analytical applications. Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.

HY-B2053R

Tolclofos-methyl (Standard)	Reference Standards Bacterial	Infection
Tolclofos-methyl (Standard) is the analytical standard of Tolclofos-methyl (HY-B2053). This product is intended for research and analytical applications. Tolclofos-methyl is an organophosphorus fungicide. Tolclofos-methyl undergoes photoinduced oxidative degradation to form oxo-analog derivatives. Tolclofos-methyl inhibits spore division in fungi and oomycetes, induces cytoplasmic leakage, and interferes with flagellar movement. Tolclofos-methyl is rapidly metabolized and excreted in rodents. Tolclofos-methyl can be used in studies related to fungal infections .

HY-W741033

Demeton-S sulfone	Drug Metabolite	Others
Demeton-S sulfone is an oxidative metabolite of the organophosphorus insecticide Disulfoton .

HY-181136

Antiestrogenic agent-1	Estrogen Receptor/ERR	Metabolic Disease Cancer
Antiestrogenic agent-1, an organophosphorus 13α-estrone derivative, is an antiestrogenic agent. Antiestrogenic agent-1 can disrupt estrogen signaling by inhibiting estrogen-mediated transcriptional activity. Antiestrogenic agent-1 can inhibit cancer cells proliferation, migration, invasion and induce G1-phase arrest. Antiestrogenic agent-1 mitigates estrogen-induced uterine growth in immature rats and inhibits tumor growth in a murine triple-negative breast cancer mice model. Antiestrogenic agent-1 can be used for the researches of cancer and endocrinology,such as breast cancer, oropharyngeal squamous cell carcinoma .

HY-W275793

Tripropionin Glycerol tripropionate	Carboxylesterase (CES)	Others
Tripropionin (Glycerol tripropionate) is a triglyceride that can be hydrolyzed by carboxylic esterase from carrots. Tripropionin can serve as the oil phase for constructing high-performance lipid nanoemulsion droplets, enabling efficient encapsulation of Combretastatin A4 (HY-N2146) to achieve its stable storage and controlled release .

Cat. No.	Product Name	Chemical Structure

HY-118165S

Phenthoate-d6
Phenthoate-d₆ is deuterium labeled Phenthoate. Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor .

HY-126199S

(Z)-Tetrachlorvinphos-d6
(Z)-Tetrachlorvinphos-d₆ is the deuterium labeled Tetrachlorvinphos (HY-126199). Tetrachlorvinphos is an organophosphorus pesticide that has the activity of inhibiting cholinesterase. Tetrachlorvinphos is used as a pesticide, mainly for the control of pests. Tetrachlorvinphos has low toxicity to mammals .

HY-B1881S

Pirimiphos-methyl-d6
Pirimiphos-methyl-d₆ is the deuterium labeled Pirimiphos-methyl (HY-B1881) . Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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