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riboswitch ligand

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121295
    Roseoflavin

    		Bacterial Infection
    Roseoflavin, a natural pigment originally isolated from Streptomyces davawensis, is an antimetabolite analog of Riboflavin and flavin mononucleotide that has antimicrobial properties .
    Roseoflavin
  • HY-19487
    Ribocil

    		Bacterial Infection
    Ribocil is a selective inhibitor targeting the bacterial FMN riboswitch, regulating the bacterial riboflavin riboswitch. Ribocil competitively binds to the FMN binding site, mimicking the natural ligand FMN to induce conformational changes in the riboswitch, inhibiting ribB gene expression, reducing riboflavin synthesis, and thus inhibiting bacterial growth. Ribocil strongly inhibits GFP expression (EC50=0.3 μM). Ribocil exhibits in vivo antibacterial activity in a mouse model and can be used to study antibacterial drugs related to drug-resistant bacterial infections and bacterial riboflavin metabolic pathways[1][2].
    Ribocil
  • HY-W907070
    5-Amino-1-(pyridin-3-yl)-1h-imidazole-4-carboxamide

    		Glycosidase Others
    5-Amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide is a riboswitch ligand. 5-Amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide effectively activates riboswitches during in vitro transcription and induces β-galactosidase expression .
    5-Amino-1-(pyridin-3-yl)-1h-imidazole-4-carboxamide
  • HY-175761
    Riboswit-modulator-1

    		Bacterial Infection
    Riboswit-modulator-1 (Compound A1), a covalent RNA ligand, is a bacterial Flavin mononucleotide (FMN) riboswitch modulator. Riboswit-modulator-1 modifies unpaired guanine residues (G11 and G62) proximal to the FMN-binding site through a proximity-driven mechanism, and interferes with its conformational transitions. Riboswit-modulator-1 acts as a negative antagonist by eliciting the opposite effect of the natural effector molecule .
    Riboswit-modulator-1

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