2. Anti-infection
  3. Bacterial
  4. Ribocil

Ribocil 

Cat. No.: HY-19487 Purity: 99.44%
COA Handling Instructions

Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches.

For research use only. We do not sell to patients.

Ribocil Chemical Structure

Ribocil Chemical Structure

CAS No. : 1381289-58-2

Size Price Stock Quantity
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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 144 In-stock
Solution
10 mM * 1 mL in DMSO USD 144 In-stock
Solid
2 mg USD 92 In-stock
5 mg USD 172 In-stock
10 mg USD 290 In-stock
50 mg USD 1016 In-stock
100 mg USD 1822 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ribocil:

Ribocil Related Antibodies

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Description

Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM. Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1]

Molecular Weight

382.48

Appearance

Solid

Formula

C19H22N6OS
CAS No.
SMILES

C1(C=C(NC(=N1)C1CN(CC2C=NC(NC)=NC=2)CCC1)C1=CC=CS1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (32.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6145 mL 13.0726 mL 26.1452 mL
5 mM 0.5229 mL 2.6145 mL 5.2290 mL
10 mM 0.2615 mL 1.3073 mL 2.6145 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (3.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (3.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.25 mg/mL (3.27 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.44%

COA (254 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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Ribocil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ribocil1381289-58-2BacterialInhibitorinhibitorinhibit

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