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Cat. No.: HY-19488A Purity: 98.18% ee.: 98.69%
Handling Instructions

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

For research use only. We do not sell to patients.
Ribocil-C Chemical Structure

Ribocil-C Chemical Structure

CAS No. : 1825355-56-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
5 mg USD 90 In-stock
10 mg USD 160 In-stock
50 mg USD 720 In-stock
100 mg USD 1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Ribocil-C:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

IC50 & Target

Bacterial riboflavin riboswitches[1]

In Vitro

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis[1]. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth[1][2].

In Vivo

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed[2].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3838 mL 11.9190 mL 23.8379 mL
5 mM 0.4768 mL 2.3838 mL 4.7676 mL
10 mM 0.2384 mL 1.1919 mL 2.3838 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Ribocil-C is prepared in 10% DMSO[2].

DBA/2J mice are infected by intraperitoneal injectionwith Escherichia coli strain MB5746 (5×104 CFU per mouse) and treated by subcutaneous injection with Ribocil-C (30, 60, 120 mg/kg) or ciprofloxacin (0.5mg/kg) three times over a 24 h infection period. Spleens are aseptically collected from five mice per group and the reduction of log[CFU per g spleen tissue] is calculated on the basis of bacterial burden in spleens of the vehicle-treated (10% DMSO) control group[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C1C=C(C2=CC=CS2)NC([[email protected]]3CCCN(CC4=CN(C5=NC=CC=N5)C=N4)C3)=N1

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility


* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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