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Results for "

sting+antagonists

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162664
    STING antagonist-1

    		STING Inflammation/Immunology
    STING antagonist-1 is an antagonist of STING with an IC50 of 3.8 nM. STING antagonist-1 can be used in the research of autoimmune diseases, inflammatory diseases, and others .
    STING antagonist-1
  • HY-148644
    STING antagonist-2

    		STING Inflammation/Immunology
    STING antagonist-2 (Compound 50) is a potent STING antagonist with a pIC50 of 8.9. STING antagonist-2 has the potential for immunity research .
    STING antagonist-2
  • HY-185379
    STING antagonist-3

    		STING Inflammation/Immunology
    STING antagonist-3 is a potent STING antagonist with an IC50 of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders .
    STING antagonist-3
  • HY-180120
    UM-203

    		STING IKK NF-κB IFNAR Interleukin Related Inflammation/Immunology
    UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus .
    UM-203

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