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transforming growth factor β-activated kinase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (1) COX (1) IRAK (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (1) MAP3K (1) MMP (1) NF-κB (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Neurological Disease (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Targets Recommended: TGF-β Receptor TGF-beta/Smad FGFR GHR VEGFR PDGFR EGFR IGF-1R GHSR Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-169949

TAK-756	MAP3K NF-κB MMP Leukotriene Receptor	Inflammation/Immunology
TAK-756 is a selective transforming growth factor β-activated kinase 1 (TAK1) inhibitor with a target pIC₅₀ of 8.6. TAK-756 can inhibit TAK1 autophosphorylation and downstream NF-κB phosphorylation, suppress the production of inflammatory and catabolic factors such as MMP-3 and IL-6. TAK-756 exhibits anti-inflammatory effects in a rat joint inflammation model. TAK-756 can be used for the research of inflammatory joint disease, osteoarthritis .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity .

HY-12383S

Pelubiprofen-13C,d3	Isotope-Labeled Compounds COX	Neurological Disease Inflammation/Immunology
Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

Cat. No.	Product Name	Chemical Structure

HY-12383S

Pelubiprofen-13C,d3
Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

Host:	Mouse (3) Rabbit (4)
Reactivity:	Human (7) Rat (6) Mouse (6) Monkey (2)
Application:	ICC/IF (3) IP (3) WB (7) FC (1) ELISA (1)
Isotype:	IgG (4) IgG2b (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Phosphorylated (2) Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80908

	TAK1 Antibody (YA663) 1 Publications Verification MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB	Human, Mouse, Rat, Monkey
	TAK1 Antibody (YA663) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TAK1.

HY-P86498

	TAK1 Antibody (YA6190) MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TAK1 Antibody (YA6190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TAK1.

HY-P80908A

	TAK1 Antibody (YA663)(PBS only) MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB	Human, Mouse, Rat, Monkey
	TAK1 Antibody (YA663) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TAK1.

HY-P80858

	Phospho-TAK1 (Ser439) Antibody (YA144) 1 Publications Verification MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, ICC/IF, IP	Human, Mouse, Rat
	Phospho-TAK1 (Ser439) Antibody (YA144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TAK1 (Ser439).

HY-P810681

	Phospho-TAK1 (Ser412) Antibody (YA9939) MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, FC	Human, Mouse, Rat
	Phospho-TAK1 (Ser412) Antibody (YA9939) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-TAK1 (Ser412).

HY-P80858A

	Phospho-TAK1 (Ser439) Antibody (YA144)(PBS only) MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, ICC/IF, IP	Human, Mouse, Rat
	Phospho-TAK1 (Ser439) Antibody (YA144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TAK1 (Ser439).

HY-P85540

	TAB1(N-term) Antibody (YA5232) 2310012M03Rik; 3'-Tab1; MAP3K7IP 1; MAP3K7IP1; MGC57664; Mitogen activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB 1; TAB1; TAB1_HUMAN; TAK1 binding protein 1; TAK1-binding protein 1; TGF beta activated kinase 1 binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta activated kinase binding protein 1.	WB	Human
	TAB1(N-term) Antibody (YA5232) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TAB1(N-term).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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