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wortmanin

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4

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10197
    Wortmannin
    160+ Cited Publications

    SL-2052; KY-12420

    		 Organoid PI3K Polo-like Kinase (PLK) Autophagy Antibiotic Cancer
    Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively .
    Wortmannin
  • HY-10197R
    Wortmannin (Standard)

    SL-2052 (Standard); KY-12420 (Standard)

    		 Organoid Reference Standards PI3K Polo-like Kinase (PLK) Autophagy Antibiotic Cancer
    Wortmannin (Standard) is the analytical standard of Wortmannin. This product is intended for research and analytical applications. Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively .
    Wortmannin (Standard)
  • HY-132003
    Wortmannin-Rapamycin Conjugate 1

    		Akt Cancer
    Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmannin-rapamycin conjugate with potent antitumor activities and a fine water solubility. Wortmannin-Rapamycin Conjugate 1 can inhibit the AKT phosphorylation in the tumor and can be used for cancer research .
    Wortmannin-Rapamycin Conjugate 1
  • HY-126083
    17β-Hydroxywortmannin

    Wortmannin-17β-ol

    		 PI3K Others Cancer
    17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM . 17β-Hydroxywortmannin exhibits antitumor activity .
    17β-Hydroxywortmannin

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