Wortmannin-Rapamycin Conjugate 1
Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmannin-rapamycin conjugate with potent antitumor activities and a fine water solubility. Wortmannin-Rapamycin Conjugate 1 can inhibit the AKT phosphorylation in the tumor and can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1067892-47-0
- Formula: C88H131N3O23
- Molecular Weight:1598.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Wortmannin-Rapamycin Conjugate 1 (15 mg/kg, i.v., 2 h) significantly inhibits the AKT phosphorylation in the tumor of U87MG mouse xenogrgaft model[1].
Wortmannin-Rapamycin Conjugate 1 (15 mg/kg, i.v., weekly for 20 d ) completely inhibits the growth of HT29 colon tumor, a non-sensitive colon tumor model to rapamycin or wortmannin analogues in tumor-bearing mice[1].
Wortmannin-Rapamycin Conjugate 1 (30 mg/kg, i.v., weekly for 38 d ) exerts a substantial regression of larger A498 tumors with 200 μg Bevacizumab (HY-P9906) in A498 tumor-bearing mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT29 bearing nude mice[1]
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Dosage:15 mg/kg, weekly for 20 d
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Administration:Intravenous injection (i.v.)
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Result:Showed no significant growth in tumor volume while an equivalent physical mixture of the Rapamycin and Wortmannin derivative was poorly tolerated.
Chemical Information
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CAS No. 1067892-47-0
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Molecular Weight 1598.99
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Formula C88H131N3O23
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SMILES
C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(C)CCCN(C)C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)OC(CCCCCCC(O[C@H]5[C@@H](C[C@@H](CC5)C[C@H]([C@@]6([H])OC([C@@]7([H])N(CCCC7)C(C([C@@]8(O[C@](CC[C@H]8C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C6)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wortmannin-Rapamycin Conjugate 1 Related Classifications
HY-132003 Related Classifications
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