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ykl40

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By Targets:	Glycosidase (2) Potassium Channel (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

CHI3L1-IN-1	Glycosidase Potassium Channel	Inflammation/Immunology Cancer
CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC₅₀ of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC₅₀ of 2.3 μM .

CHI3L1-IN-2	Glycosidase	Others
CHI3L1-IN-2 (Compound 36) is a CHI3L1 (Chitinase-3-Like Protein 1) inhibitor. CHI3L1-IN-2 inhibits the? interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), with an IC₅₀ of 26 nM. CHI3L1, also known as YKL-40, is a glycoprotein associated with inflammation, fibrosis, and cancer .

CHI3L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHI3L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHI3L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chi3l1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Chi3l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chi3l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76702

	CHI3L1 Protein, Mouse (HEK293, His) 1 Publications Verification Chitinase-3-Like protein 1; 39 kDa Synovial Protein; CGP-39; GP-39; hCGP-39; ykl-40	Mouse	HEK293
	The CHI3L1 protein is a carbohydrate-binding lectin with a preference for chitin that is involved in tissue remodeling and cellular adaptation to environmental changes. It is involved in Th2 inflammation, IL-13-induced inflammation, allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation, M2 macrophage differentiation and pathogenic intestinal bacterial invasion. CHI3L1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHI3L1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P700039AF

	Animal-Free CHI3L1 Protein, Human (His) Chitinase-3-Like protein 1; 39 kDa Synovial Protein; Cartilage Glycoprotein 39; CGP-39; GP-39; hCGP-39; ykl-40; CHI3L1	Human	E. coli
	The CHI3L1 protein is a binding lectin that lacks chitinase activity. CHI3L1 contributes to tissue remodeling, cellular adaptation to environmental changes, and T helper type 2 inflammatory responses. CHI3L1 also controls hyperoxia-induced injury, inflammation, and epithelial cell apoptosis. Animal-Free CHI3L1 Protein, Human (His) is the recombinant human-derived animal-FreeCHI3L1 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70030

	CHI3L1 Protein, Human (HEK293, His) 4 Publications Verification rHuChitinase-3-like protein 1/CHI3L1, His; Chitinase-3-Like protein 1; 39 kDa Synovial Protein; Cartilage Glycoprotein 39; CGP-39; GP-39; hCGP-39; ykl-40; CHI3L1	Human	HEK293
	The CHI3L1 protein is a binding lectin that lacks chitinase activity. CHI3L1 contributes to tissue remodeling, cellular adaptation to environmental changes, and T helper type 2 inflammatory responses. CHI3L1 also controls hyperoxia-induced injury, inflammation, and epithelial cell apoptosis. CHI3L1 Protein, Human (HEK293, His) is the recombinant human-derived CHI3L1 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P87276

	YKL-40/CHI3L1 Antibody (YA6959) 39 kDa synovial protein antibody; ASRT7 antibody; Cartilage glycoprotein 39 antibody; CGP-39 antibody; CGP39 antibody; CH3L1_HUMAN antibody; CHI3L1 antibody; chitinase 3 like 1 (cartilage glycoprotein 39) antibody; chitinase 3 like 1 antibody; Chitinase 3 like protein 1 precursor antibody	WB, IHC-P	Human
	YKL-40/CHI3L1 Antibody (YA6959) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to YKL-40/CHI3L1.

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HY-RS02626

CHI3L1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CHI3L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHI3L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23173

Chi3l1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Chi3l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chi3l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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