2. Membrane Transporter/Ion Channel
  3. Sec61
  4. Sec61-IN-1

Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].

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Sec61-IN-1

Sec61-IN-1 화학구조

CAS No. : 2484865-42-9

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Sec61-IN-1 Related Antibodies

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제품 설명

Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].

In Vitro

Sec61-IN-1 (compound A317) enhances T cell cytotoxicity in U87 glioma cells[2].
Sec61-IN-1 shows lower IC50for cytotoxicity in GBM12 and GBM38 PDX cell lines with SEC61G-EGFR dual amplification than in brain, with IC50values ??of 96.6 ng/mL (GBM12) and 163.8 ng/mL (GBM38), respectively. It shows no effect in GBM6 (non-SEC61G amplified) PDX cell line with EGFR amplification[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sec61-IN-1 Related Antibodies
In Vivo

Sec61-IN-1 (25 mg/kg; intravenous injection; single dose) is detected at a concentration of 400 ng/g in mouse brain tissue 45 min after injection (5-7% of the plasma concentration)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

430.53

화학식

C23H22N6OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN1CC2=CC=NC=C2)NC3=NC([C@@H]4N(C5=NC=CC=C5)CCC4)=CS3
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 125 mg/mL (290.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3227 mL 11.6136 mL 23.2272 mL
5 mM 0.4645 mL 2.3227 mL 4.6454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3227 mL 11.6136 mL 23.2272 mL 58.0680 mL
5 mM 0.4645 mL 2.3227 mL 4.6454 mL 11.6136 mL
10 mM 0.2323 mL 1.1614 mL 2.3227 mL 5.8068 mL
15 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
20 mM 0.1161 mL 0.5807 mL 1.1614 mL 2.9034 mL
25 mM 0.0929 mL 0.4645 mL 0.9291 mL 2.3227 mL
30 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL
40 mM 0.0581 mL 0.2903 mL 0.5807 mL 1.4517 mL
50 mM 0.0465 mL 0.2323 mL 0.4645 mL 1.1614 mL
60 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
80 mM 0.0290 mL 0.1452 mL 0.2903 mL 0.7258 mL
100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.5807 mL
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Sec61-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sec61-IN-12484865-42-9Sec61Sec61 complex, SecY, Sec61 channelInhibitorinhibitorinhibit

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상품명:
Sec61-IN-1
Cat. No.:
HY-139615
수량:
MCE Japan Authorized Agent:

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