SHLP2  (Synonyms: Small humanin-like peptide 2)

SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease^[1][2].

SHLP2 (2.5 μM, 24 h) protects against mitochondrial dysfuction in SH-SY5Y cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHLP2 (2.5 mg/kg, i.p., twice a day) rescues the MPTP-induced dopamine loss in the striatum in C57BL/6J mice exposed to MPTP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3017.50

C₁₄₂H₂₁₄N₃₆O₃₅S

1191923-93-9

Solid

White to off-white

Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser

MGVKFFTLSTRFFPSVQRAVPLWTNS

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Nashine S, et al. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9(5): 1102.  [Content Brief]

  [2]. Kim, S. J., et al., (2024). A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Molecular psychiatry, 29(2), 505–517.  [Content Brief]

  [3]. Kim, S. K., et al., (2023). Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nature communications, 14(1), 4321.  [Content Brief]