2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. nAChR SARS-CoV
  4. Simpinicline

Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM.

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Simpinicline

Simpinicline Chemische Struktur

CAS. Nr. : 753015-44-0

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10 mM * 1 mL in DMSO
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Beschreibung

Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].

Klinische Studie
Molekulargewicht

175.23

Formel

C10H13N3
CAS. Nr.
Appearance

Oil

Color

Yellow to brown

SMILES

[C@@H]1(CCNC1)/C=C/C2=CN=CN=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 100 mg/mL (570.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7068 mL 28.5339 mL 57.0679 mL
5 mM 1.1414 mL 5.7068 mL 11.4136 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.45%

SDS (252 KB)

COA (245 KB) HNMR (189 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7068 mL 28.5339 mL 57.0679 mL 142.6696 mL
5 mM 1.1414 mL 5.7068 mL 11.4136 mL 28.5339 mL
10 mM 0.5707 mL 2.8534 mL 5.7068 mL 14.2670 mL
15 mM 0.3805 mL 1.9023 mL 3.8045 mL 9.5113 mL
20 mM 0.2853 mL 1.4267 mL 2.8534 mL 7.1335 mL
25 mM 0.2283 mL 1.1414 mL 2.2827 mL 5.7068 mL
30 mM 0.1902 mL 0.9511 mL 1.9023 mL 4.7557 mL
40 mM 0.1427 mL 0.7133 mL 1.4267 mL 3.5667 mL
50 mM 0.1141 mL 0.5707 mL 1.1414 mL 2.8534 mL
60 mM 0.0951 mL 0.4756 mL 0.9511 mL 2.3778 mL
80 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7834 mL
100 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.4267 mL
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Simpinicline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simpinicline753015-44-0OC-02OC02OC 02nAChRSARS-CoVNicotinic acetylcholine receptorsSARS coronavirusInhibitorinhibitorinhibit

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