2. Anti-infection
  3. Dengue Virus Flavivirus
  4. Sinococuline

Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.

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Sinococuline

Sinococuline 화학구조

CAS No. : 109351-36-2

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50 mg   견적 받기  

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Sinococuline Related Antibodies

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제품 설명

Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
37 μM
Compound: 9
Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
[PMID: 20426456]
Hepatocyte IC50
4.5 μM
Compound: 2
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
[PMID: 18456502]
In Vitro

Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells[1].
Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sinococuline Related Antibodies
In Vivo

Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection[1]
Dosage: 0.5, 1.0, 2.0 mg/kg/day
Administration: I.p. twice a day for 5 days
Result: Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day.
The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
분자량

333.38

화학식

C18H23NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4O)C[C@H](O)[C@@H]1O
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
순도&문서
References
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Sinococuline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sinococuline109351-36-2Dengue VirusFlavivirusDENVdenguevirustumorInhibitorinhibitorinhibit

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상품명:
Sinococuline
Cat. No.:
HY-N11096
수량:
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