2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SuO-Glu-Val-Cit-PAB-MMAE

SuO-Glu-Val-Cit-PAB-MMAE  (Synonyms: NHS-Glutarate-Val-Cit-PAB-MMAE)

Cat. No.: HY-130989 Purity: 99.38%
COA
SDS
Handling Instructions Technical Support

SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SuO-Glu-Val-Cit-PAB-MMAE

SuO-Glu-Val-Cit-PAB-MMAE 화학구조

CAS No. : 1895916-24-1

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

SuO-Glu-Val-Cit-PAB-MMAE Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SuO-Glu-Val-Cit-PAB-MMAE Related Antibodies
분자량

1334.60

화학식

C67H103N11O17
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC(ON4C(CCC4=O)=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C
선적

Shipping with dry ice.
보관

-80°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

용액&용해도
In Vitro: 

DMSO : 100 mg/mL (74.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7493 mL 3.7464 mL 7.4929 mL
5 mM 0.1499 mL 0.7493 mL 1.4986 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7493 mL 3.7464 mL 7.4929 mL 18.7322 mL
5 mM 0.1499 mL 0.7493 mL 1.4986 mL 3.7464 mL
10 mM 0.0749 mL 0.3746 mL 0.7493 mL 1.8732 mL
15 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
20 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9366 mL
25 mM 0.0300 mL 0.1499 mL 0.2997 mL 0.7493 mL
30 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6244 mL
40 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
50 mM 0.0150 mL 0.0749 mL 0.1499 mL 0.3746 mL
60 mM 0.0125 mL 0.0624 mL 0.1249 mL 0.3122 mL
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SuO-Glu-Val-Cit-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SuO-Glu-Val-Cit-PAB-MMAE1895916-24-1NHS-Glutarate-Val-Cit-PAB-MMAEDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Inquiry Information

상품명:
SuO-Glu-Val-Cit-PAB-MMAE
Cat. No.:
HY-130989
수량:
MCE Japan Authorized Agent:

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