Tau protein (592-597), human TFA 

Tau protein (592-597), human TFA is a peptide fragment of human Tau protein. The dysfunction of Tau protein is involved in neurodegeneration and dementia^[1].

Tau protein function: A microtubule-associated protein that stabilizes neuronal microtubules and regulates axonal transport; upon abnormal hyperphosphorylation, it dissociates and aggregates into neurofibrillary tangles (NFTs), driving neurodegeneration.
Residues 592–597 (PHF6) – Aggregation core: VQIINK is the shortest functional segment mediating Tau homo-oligomerization and amyloid fibrillization; it rapidly forms β-sheet fibrils in vitro, is highly abundant in NFTs within Alzheimer's disease brains, and serves as a specific marker for Tau.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

868.94

C₃₆H₆₃F₃N₁₀O₁₁

2703746-44-3

Solid

White to off-white

Ac-Val-Gln-Ile-Ile-Asn-Lys-NH2

Ac-VQIINK-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Macdonald JA, et al. Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord. Acta Neuropathol Commun. 2019 Mar 18;7(1):44.  [Content Brief]