2. PROTAC
  3. PROTAC Linkers
  4. TCO-amine

TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

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TCO-amine

TCO-amine Estructura química

No. CAS : 1799962-26-7

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Other Forms of TCO-amine:

TCO-amine Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Descripciòn

TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-amine Related Antibodies
Peso molecular

226.32

Fòrmula

C12H22N2O2
No. CAS
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(NCCCN)OC1CC/C=C/CCC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (441.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4185 mL 22.0926 mL 44.1852 mL
5 mM 0.8837 mL 4.4185 mL 8.8370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4185 mL 22.0926 mL 44.1852 mL 110.4631 mL
5 mM 0.8837 mL 4.4185 mL 8.8370 mL 22.0926 mL
10 mM 0.4419 mL 2.2093 mL 4.4185 mL 11.0463 mL
15 mM 0.2946 mL 1.4728 mL 2.9457 mL 7.3642 mL
20 mM 0.2209 mL 1.1046 mL 2.2093 mL 5.5232 mL
25 mM 0.1767 mL 0.8837 mL 1.7674 mL 4.4185 mL
30 mM 0.1473 mL 0.7364 mL 1.4728 mL 3.6821 mL
40 mM 0.1105 mL 0.5523 mL 1.1046 mL 2.7616 mL
50 mM 0.0884 mL 0.4419 mL 0.8837 mL 2.2093 mL
60 mM 0.0736 mL 0.3682 mL 0.7364 mL 1.8411 mL
80 mM 0.0552 mL 0.2762 mL 0.5523 mL 1.3808 mL
100 mM 0.0442 mL 0.2209 mL 0.4419 mL 1.1046 mL
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TCO-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-amine1799962-26-7PROTAC LinkersInhibitorinhibitorinhibit

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Nombre del producto:
TCO-amine
Cat. No.:
HY-141176
Cantidad:
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