2. Anti-infection
  3. Bacterial
  4. Thiocoraline

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms.

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Kundenspezifische Peptidsynthese

Thiocoraline

Thiocoraline Chemische Struktur

CAS. Nr. : 173046-02-1

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Thiocoraline Related Antibodies

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Beschreibung

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms[1].

Cellular Effect
Cell Line Type Value Description References
A549 EC50
0.01 μM
Compound: 1
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
[PMID: 26444379]
A549 GI50
4.8 nM
Compound: thiocoraline A
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 17571868]
DU-145 GI50
1.9 nM
Compound: thiocoraline A
Cytotoxicity against human DU145 cells after 72 hrs by SRB assay
Cytotoxicity against human DU145 cells after 72 hrs by SRB assay
[PMID: 17571868]
HeLa GI50
1.3 nM
Compound: thiocoraline A
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
[PMID: 17571868]
HT-29 GI50
3.9 nM
Compound: thiocoraline A
Cytotoxicity against human HT29 cells after 72 hrs by SRB assay
Cytotoxicity against human HT29 cells after 72 hrs by SRB assay
[PMID: 17571868]
K562 GI50
1.3 nM
Compound: thiocoraline A
Cytotoxicity against human K562 cells after 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 72 hrs by SRB assay
[PMID: 17571868]
LNCaP GI50
3 nM
Compound: thiocoraline A
Cytotoxicity against human LNCaP cells after 72 hrs by SRB assay
Cytotoxicity against human LNCaP cells after 72 hrs by SRB assay
[PMID: 17571868]
LoVo GI50
212.3 nM
Compound: thiocoraline A
Cytotoxicity against doxorubicin resistant human LoVo cells after 72 hrs by SRB assay
Cytotoxicity against doxorubicin resistant human LoVo cells after 72 hrs by SRB assay
[PMID: 17571868]
LoVo GI50
7.2 nM
Compound: thiocoraline A
Cytotoxicity against human LoVo cells after 72 hrs by SRB assay
Cytotoxicity against human LoVo cells after 72 hrs by SRB assay
[PMID: 17571868]
PANC-1 GI50
2.5 nM
Compound: thiocoraline A
Cytotoxicity against human PANC1 cells after 72 hrs by SRB assay
Cytotoxicity against human PANC1 cells after 72 hrs by SRB assay
[PMID: 17571868]
SK-BR-3 GI50
2.2 nM
Compound: thiocoraline A
Cytotoxicity against human SK-BR3 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-BR3 cells after 72 hrs by SRB assay
[PMID: 17571868]
SK-MEL-28 GI50
3 nM
Compound: thiocoraline A
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by SRB assay
[PMID: 17571868]
Molekulargewicht

1157.41

Formel

C48H56N10O12S6
CAS. Nr.
Versand

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Speicherung

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Thiocoraline Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiocoraline173046-02-1BacterialP388A549HT-29MEL-28antitumorantimicrobialdepsipeptideMicromonosporaInhibitorinhibitorinhibit

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