2. Metabolic Enzyme/Protease Apoptosis
  3. PAI-1 Apoptosis
  4. TM5441 sodium

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence.

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CAS No. : 2319722-53-5

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Top Publications Citing Use of Products

    TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Jun 6;11(23):eadu2695.  [Abstract]

    Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of TM5441 (0-1000 μM).

    TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525.  [Abstract]

    TM5441 decreased SERPINE1, TGFB1 and CDH6.

    TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525.  [Abstract]

    TM5441 (PAI-1 inhibitor) or vehicle (DMSO) to the previous transwell systems. TM5441 treatment in the podocytes decreased TGFB1 and FN1.

    TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Sep 27;13(1):16210.  [Abstract]

    Paracrine senescence effects were largely abolished by the addition of the Serpin E1 inhibitor TM5441 (10 μM, pre-incubate for 1 hour) to the conditioned medium.

    TM5441 sodium purchased from MedChemExpress. Usage Cited in: Res Sq. 2023 Jun 5:rs.3.rs-2986934.

    HEK293 cells with NC or ALDH1L2 siRNA were treated with PAI-1 inhibitor TM5441 and then subjected to TGF-b1 treatment.

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    Description

    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2].

    Masse moléculaire

    450.80

    Formule

    C21H16ClN2NaO6
    CAS No.
    SMILES

    ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O[Na])=O)=C1
    Livraison

    Room temperature in continental US; may vary elsewhere.
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    TM5441 sodium Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TM54412319722-53-5TM 5441TM-5441PAI-1ApoptosisPlasminogen activator inhibitor-1HT1080HCT116DaoyMDA-MB-231JurkatapoptosisInhibitorinhibitorinhibit

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