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TNS sodium  (Synonyms: 6-(p-Tolylamino)naphthalene-2-sulfonate sodium)

製品番号: HY-W250727 純度: 99.97%
COA 取扱説明書 Technical Support

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively.

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TNS sodium

TNS sodium 構造式

CAS 番号 : 53313-85-2

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
100 mg $35 在庫あり
250 mg $60 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

TNS sodium 関連抗体

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製品説明

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively[1].

体外実験

TNS (10 μM TNS, 10 μM β-LG; 298 K) sodium binds to purified bovine β-lactoglobulin (β-LG) at a distance of 2.5 nm from the Trp19 residue of β-LG at pH 7.0[1].
TNS (sodium) (25 μM TNS, 25 μM β-LG; incubated with 0-1.2 M NaCl) binding to purified bovine β-lactoglobulin (β-LG) at pH 7.0 is disrupted by increasing ionic strength (via NaCl), with the most significant disruption occurring at NaCl concentrations between 0 M and 0.25 M[1].
TNS (10 μM TNS, 10 μM β-LG; 20 min) sodium binding to purified bovine β-lactoglobulin (β-LG) at pH 7.0 stabilizes its fold, increasing the guanidine hydrochloride concentration required for unfolding from a midpoint of 2.3 M to 3.9 M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNS sodium 関連抗体
分子量

335.36

分子式

C17H14NNaO3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C2C=C(NC3=CC=C(C)C=C3)C=CC2=C1)(O[Na])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 4 mg/mL (11.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9819 mL 14.9094 mL 29.8187 mL
5 mM 0.5964 mL 2.9819 mL 5.9637 mL
10 mM 0.2982 mL 1.4909 mL 2.9819 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション

純度: 99.97%

COA (247 KB) HNMR (260 KB) RP-HPLC (246 KB) MS (68 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9819 mL 14.9094 mL 29.8187 mL 74.5468 mL
5 mM 0.5964 mL 2.9819 mL 5.9637 mL 14.9094 mL
10 mM 0.2982 mL 1.4909 mL 2.9819 mL 7.4547 mL
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TNS sodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNS53313-85-26-(p-Tolylamino)naphthalene-2-sulfonateFluorescent Dyesodium dodecylbenzene sulfonateguanidine hydrochlorideTrp19 residueelectrostatic interactionscentral hydrophobic calyxbovine β-LGβ-lactoglobulinsodium dodecyl sulfatehydrophobic interactionshydrogen bondsInhibitorinhibitorinhibit

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TNS sodium
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