2. Anti-infection
  3. Bacterial
  4. Triclocarban-d4

Triclocarban-d4  (Synonyms: 3,4,4′-Trichlorocarbanilide-d4)

Cat. No.: HY-B1805S Pureza: 98.09%
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Instrucciones de manejo Technical Support

Triclocarban-d4 is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.

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Triclocarban-d<sub>4</sub>

Triclocarban-d4 Estructura química

No. CAS : 1219799-29-7

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
10 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
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Other Forms of Triclocarban-d4:

Triclocarban-d4 Related Antibodies

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Descripciòn

Triclocarban-d4 is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triclocarban-d4 Related Antibodies
Peso molecular

319.61

Fòrmula

C13H5D4Cl3N2O
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1NC(NC2=CC(Cl)=C(C=C2)Cl)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (312.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1288 mL 15.6441 mL 31.2881 mL
5 mM 0.6258 mL 3.1288 mL 6.2576 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1288 mL 15.6441 mL 31.2881 mL 78.2203 mL
5 mM 0.6258 mL 3.1288 mL 6.2576 mL 15.6441 mL
10 mM 0.3129 mL 1.5644 mL 3.1288 mL 7.8220 mL
15 mM 0.2086 mL 1.0429 mL 2.0859 mL 5.2147 mL
20 mM 0.1564 mL 0.7822 mL 1.5644 mL 3.9110 mL
25 mM 0.1252 mL 0.6258 mL 1.2515 mL 3.1288 mL
30 mM 0.1043 mL 0.5215 mL 1.0429 mL 2.6073 mL
40 mM 0.0782 mL 0.3911 mL 0.7822 mL 1.9555 mL
50 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5644 mL
60 mM 0.0521 mL 0.2607 mL 0.5215 mL 1.3037 mL
80 mM 0.0391 mL 0.1956 mL 0.3911 mL 0.9778 mL
100 mM 0.0313 mL 0.1564 mL 0.3129 mL 0.7822 mL
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Triclocarban-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triclocarban-d41219799-29-73,4,4′-Trichlorocarbanilide-d4BacterialInhibitorinhibitorinhibit

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Nombre del producto:
Triclocarban-d4
Cat. No.:
HY-B1805S
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