2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin-IN-68

Tubulin-IN-68 is a tubulin inhibitor with an IC50 of 19.3 μM. Tubulin-IN-68 exhibits antiproliferative activity against human cancer cells. Tubulin-IN-68 induces G2/M phase cell cycle arrest. Tubulin-IN-68 induces apoptosis. Tubulin-IN-68 can be used in the research of colorectal cancer, hepatocellular carcinoma, breast cancer, and T-cell leukemia.

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Tubulin-IN-68

Tubulin-IN-68 Chemical Structure

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Tubulin-IN-68 Related Antibodies

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Description

Tubulin-IN-68 is a tubulin inhibitor with an IC50 of 19.3 μM. Tubulin-IN-68 exhibits antiproliferative activity against human cancer cells. Tubulin-IN-68 induces G2/M phase cell cycle arrest. Tubulin-IN-68 induces apoptosis. Tubulin-IN-68 can be used in the research of colorectal cancer, hepatocellular carcinoma, breast cancer, and T-cell leukemia[1].

In Vitro

Tubulin-IN-68 (72 h) potently inhibits the proliferation of HepG2, HCT116, Jurkat, and MCF-7 human cancer cell lines with IC50 values ranging from 0.299 μM to 3.948 μM[1].
Tubulin-IN-68 (1-10 μM; 24 h) disrupts the microtubule network structure in HCT116 cells[1].
Tubulin-IN-68 (0.5-2 μM; 10 days) inhibits the clonogenicity of HCT116 cells in a dose-dependent manner[1].
Tubulin-IN-68 (2.5-5 μM; 24 h) induces dose-dependent G2/M phase arrest in HCT116 cells, reaching a maximum of 90.16% of cells in G2/M at 5 μM[1].
Tubulin-IN-68 (0.5-2 μM; 48 h) induces dose-dependent apoptosis in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin-IN-68 Related Antibodies

Immunofluorescence[1]

Cell Line: human HCT116 colorectal cancer cell line
Concentration: 1, 3, 10 μM
Incubation Time: 24 h
Result: Caused fragmented, disorganized microtubule networks at all tested concentrations, mirroring the phenotype induced by colchicine treatment.

Cell Proliferation Assay[1]

Cell Line: human HCT116 colorectal cancer cell line
Concentration: 0.5, 1, 2 μM
Incubation Time: 10 days
Result: Inhibited colony formation in a dose-dependent manner, with decreasing colony numbers observed as compound concentration increased.

Cell Cycle Analysis[1]

Cell Line: human HCT116 colorectal cancer cell line
Concentration: 2.5, 3.75, 5 μM
Incubation Time: 24 h
Result: Induced dose-dependent G2/M phase arrest, with the proportion of cells in G2/M phase increasing from 26.33% (control) to 44.17% (2.5 μM), 88.09% (3.75 μM), and 90.16% (5 μM).

Apoptosis Analysis[1]

Cell Line: human HCT116 colorectal cancer cell line
Concentration: 0.5, 1, 2 μM
Incubation Time: 48 h
Result: Induced a dose-dependent increase in apoptotic cells, with statistically significant increases observed at all tested concentrations relative to control.
Molecular Weight

422.50

Formula

C23H22N2O4S
SMILES

COC1=C(OC)C(OC)=CC(SC2=C(C3=CC=C(OC)C=C3)N=C4C=CC=CN42)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Tubulin-IN-68 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin-IN-68Microtubule/TubulinApoptosiscolorectal cancerG2/M cell cycle arrestcellular apoptosishepatocellular cancert-cell leukemiamicrotubule polymerizationcolchicine-binding sitehuman cancer cellstubulinbreast cancerInhibitorinhibitorinhibit

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