2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease
  3. Microtubule/Tubulin Farnesyl Transferase
  4. Tubulin polymerization-IN-25

Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

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Tubulin polymerization-IN-25

Tubulin polymerization-IN-25 Chemical Structure

CAS No. : 2490538-46-8

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Tubulin polymerization-IN-25 Related Antibodies

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Description

Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1].

IC50 & Target

IC50: 1.11 μM (Tubulin); 0.39 μM (FTase)[1]
Cellular Effect
Cell Line Type Value Description References
MDA-MB-435 GI50
19 1
Compound: 74
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
[PMID: 34101463]
MDA-MB-435 GI50
19 1
Compound: 74
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition
[PMID: 34101463]
In Vitro

Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor (MTI-FTI hybrids) acting on tubulin polymerization and on FTase[1].
Tubulin polymerization-IN-25 (10 μM, 48 h) inhibits cells growth and induces cell cytotoxicity on multiple cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-25 Related Antibodies

Cell Viability Assay[1]

Cell Line: Leukemia cells: SR, CCRF-CEM, K-562; lung cancer cell CCRF-CEMNCI-H522; melanoma cell M14
Concentration: 10 μM
Incubation Time: 48 hours
Result: Inhibited cell growth.

Cell Cytotoxicity Assay[1]

Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer)
Concentration: 10 μM
Incubation Time: 48 hours
Result: Induced cell cytotoxicity.
Masse moléculaire

414.48

Formule

C24H18N2O3S
CAS No.
SMILES

CC(C1=CC(C(C2=CC=C3NC4=C(C=CC=C4)SC3=C2)=O)=C5C=C(OC)C=CN15)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Tubulin polymerization-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-252490538-46-8Microtubule/TubulinFarnesyl TransferaseFtaseTubulin polymerization inhibitoranticancerantitumorTubulinFTaseMTI-FTI hybridsIndolizinePhenothiazineHybridsDual inhibitorAntitumor agentTubulin polymerizationFarnesyl transferase inhibitorKetoneInhibitorinhibitorinhibit

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