UCM-1336

Cat. No.: HY-155954 Purity: 99.86%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

UCM-1336 is a potent ICMT inhibitor, with an IC₅₀ of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

UCM-1336 화학구조

CAS No. : 1621535-90-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC50: 2 μM (2 μM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	2 μM Compound: 3; UCM-1336	Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31181882]
MDA-MB-231	IC₅₀	5 μM Compound: 3; UCM-1336	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
MIA PaCa-2	IC₅₀	2 μM Compound: 3; UCM-1336	Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
NIH3T3	IC₅₀	>50 μM Compound: 3; UCM-1336	Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31181882]
PANC-1	IC₅₀	7 μM Compound: 3; UCM-1336	Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
Sf9	IC₅₀	2 μM Compound: 3; UCM-1336	Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis	[PMID: 31181882]
SW-620	IC₅₀	3 μM Compound: 3; UCM-1336	Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]

분자량

423.59

화학식

C₂₆H₃₇N₃O₂

CAS No.

1621535-90-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCN(CCCCCCCC)CCC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (236.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3608 mL	11.8039 mL	23.6077 mL
5 mM	0.4722 mL	2.3608 mL	4.7215 mL
10 mM	0.2361 mL	1.1804 mL	2.3608 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.86%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (281 KB) RP-HPLC (264 KB) MS (82 KB)

Handling Instructions (2659 KB)

References

[1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3608 mL	11.8039 mL	23.6077 mL	59.0193 mL
	5 mM	0.4722 mL	2.3608 mL	4.7215 mL	11.8039 mL
	10 mM	0.2361 mL	1.1804 mL	2.3608 mL	5.9019 mL
	15 mM	0.1574 mL	0.7869 mL	1.5738 mL	3.9346 mL
	20 mM	0.1180 mL	0.5902 mL	1.1804 mL	2.9510 mL
	25 mM	0.0944 mL	0.4722 mL	0.9443 mL	2.3608 mL
	30 mM	0.0787 mL	0.3935 mL	0.7869 mL	1.9673 mL
	40 mM	0.0590 mL	0.2951 mL	0.5902 mL	1.4755 mL
	50 mM	0.0472 mL	0.2361 mL	0.4722 mL	1.1804 mL
	60 mM	0.0393 mL	0.1967 mL	0.3935 mL	0.9837 mL
	80 mM	0.0295 mL	0.1475 mL	0.2951 mL	0.7377 mL
	100 mM	0.0236 mL	0.1180 mL	0.2361 mL	0.5902 mL

UCM-1336 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCM-13361621535-90-7UCM1336UCM 1336AutophagyApoptosisICMTRasapoptosisautophagyInhibitorinhibitorinhibit

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UCM-1336

UCM-1336 Related Antibodies

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Biological Activity

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