2. Metabolic Enzyme/Protease Apoptosis
  3. Ser/Thr Protease Apoptosis
  4. Ulinastatin

Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects.

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Ulinastatin

Ulinastatin Estructura química

No. CAS : 80449-31-6

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Based on 4 publication(s) in Google Scholar

Ulinastatin Related Antibodies

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Descripciòn

Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].

In Vitro

Ulinastatin (500-5000 U; 24 hours) markedly attenuates TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ulinastatin Related Antibodies

Western Blot Analysis[1]

Cell Line: Human lung epithelial BEAS-2B cells
Concentration: 500 U, 2500 U, 5000 U
Incubation Time: 24 hours
Result: Markedly attenuated TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells.
In Vivo

Ulinastatin (10000 U/kg; i.v.; twice) significantly protects animals from LPS-induced acute lung injury (ALI), decreasing the lung wet/dry weight ratio, ALI score, total cells, neutrophils, macrophages, myeloperoxidase activity, and malondialdehyde content, factors associated with lung histological damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8-10 weeks old, 18-22 g)[1]
Dosage: 10000 U/kg
Administration: i.v.; twice (1 h before and 6 h after LPS treatment)
Result: Significantly protected animals from LPS-induced ALI.
Ensayo clínico
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

[Ulinastatin]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

H2O : 10 mg/mL (Need ultrasonic)

DMSO : 1 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Pureza y Documentación
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Ulinastatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ulinastatin80449-31-6UristatinSer/Thr ProteaseApoptosisSerine proteasesSerine endopeptidasesThreonine proteasesserine proteaseneuroprotectiveanti-inflammatoryanti-apoptoticanti-oxidant effectsInhibitorinhibitorinhibit

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Nombre del producto:
Ulinastatin
Cat. No.:
HY-134616
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