Urocortin III (mouse) free acid

製品番号: HY-P3597: Data Sheet 取扱説明書
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Urocortin III (mouse) (free acid) is a selective CRF2 receptor agonist (with high affinity for the CRF2 receptor). Urocortin III (mouse) (free acid) significantly inhibits gastric emptying without modifying colonic transit.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Urocortin III (mouse) free acid 構造式

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
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製品説明

IC₅₀ & Target

CRF2 receptor^[1]^[2].

体内実験

Urocortin III (mouse) (free acid) (120 µg/kg; i.p.; single) inhibits gastric emptying of a solid meal without modifying colonic transit in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57BL/6 mice (6 to 8-week-old)^[1].
Dosage:	12, 60, 120 µg/kg
Administration:	Intraperitoneal injection; single
Result:	Inhibited gastric emptying of the solid meal only at the highest dose, and did not alter distal colonic transit.

分子量

4171.26

分子式

C₁₈₆H₃₁₁N₅₁S₂

Sequence Shortening

FTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Martínez V, et al. Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J Pharmacol Exp Ther. 2002 May;301(2):611-7. [Content Brief]

[2]. Lewis K, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. [Content Brief]