Urotensin II (114-124), human TFA

Name: Urotensin II (114-124), human TFA
Brand: MedChemExpress
SKU: HY-P1164A
Rating: 4.5 (0 reviews)

製品番号: HY-P1164A 純度: 98.10%: Data Sheet SDS COA 取扱説明書
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Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

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Urotensin II (114-124), human TFA 構造式

容量	価格（税別）	在庫状況	数量
5 mg	$680	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1088	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

IC₅₀ & Target

GPR14^[1]

体外実験

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC₅₀=0:62±0.17 nM, n=6)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1502.59

分子式

C₆₆H₈₆F₃N₁₃O₂₀S₂

Appearance

Solid

Color

White to off-white

Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)

Sequence Shortening

ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (66.55 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6655 mL	3.3276 mL	6.6552 mL
5 mM	0.1331 mL	0.6655 mL	1.3310 mL
10 mM	0.0666 mL	0.3328 mL	0.6655 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (66.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.10%

Select Batch:

データシート (284 KB) SDS (252 KB)

COA (265 KB) RP-HPLC (87 KB) MS (143 KB) Elemental Analysis Report (124 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6655 mL	3.3276 mL	6.6552 mL	16.6379 mL
	5 mM	0.1331 mL	0.6655 mL	1.3310 mL	3.3276 mL
	10 mM	0.0666 mL	0.3328 mL	0.6655 mL	1.6638 mL
	15 mM	0.0444 mL	0.2218 mL	0.4437 mL	1.1092 mL
	20 mM	0.0333 mL	0.1664 mL	0.3328 mL	0.8319 mL
	25 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6655 mL
	30 mM	0.0222 mL	0.1109 mL	0.2218 mL	0.5546 mL
	40 mM	0.0166 mL	0.0832 mL	0.1664 mL	0.4159 mL
	50 mM	0.0133 mL	0.0666 mL	0.1331 mL	0.3328 mL
	60 mM	0.0111 mL	0.0555 mL	0.1109 mL	0.2773 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.