2. Anti-infection
  3. Influenza Virus
  4. VNT-101

VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection.

Para uso exclusivo en investigación. No vendemos a pacientes.

VNT-101

VNT-101 Estructura química

No. CAS : 2894060-67-2

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

VNT-101 Related Antibodies

Top Publications Citing Use of Products

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection[1].

In Vitro

VNT-101 exhibits potent anti-influenza A virus activity in RNP assay, with EC50 = 45 nM against H1N1/California subtype and EC50 = 21 nM against H3N2/Alaska subtype[1].
VNT-101 shows strong inhibitory effect on viral neuraminidase in NA assay, with EC50 = 8 nM against H1N1/PR8 subtype and EC50 = 4 nM against H3N2/Alaska subtype[1].
VNT-101 effectively suppresses virus-induced cytopathic effect in CPE assay, with EC50 = 5 nM against H1N1/PR8 subtype and EC50 = 4 nM against H3N2/Alaska subtype[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VNT-101 Related Antibodies
Parmacokinetics
Species Dose Route AUCinf Cmax CL Vss T1/2 Tmax F
Dog[1] 0.5 mg/kg i.v. 5.35 μM·h 8.3 μM 3.42 mL/min/kg 3.22 L/kg 16.7 h / /
Dog[1] 2 mg/kg p.o. 6.38 μM·h 1.58 μM / / 15.6 h 0.83 h 30 %
Mice[1] 20 mg/kg p.o. 52.6 μM·h 35.1 μM / / 1.87 h 0.5 h 28 %
Mice[1] 5 mg/kg i.v. 46.7 μM·h 338 μM 3.91 mL/min/kg 0.52 L/kg 4.03 h / /
Rat[1] 10 mg/kg p.o. 10.2 μM·h 1.41 μM / / 5.16 h 2.13 h 46 %
Rat[1] 100 mg/kg p.o. 122 μM·h 21.6 μM / / 5.65 h 1.5 h 54 %
Rat[1] 30 mg/kg p.o. 35.4 μM·h 7.67 μM / / 5.49 h 0.42 h 53 %
Rat[1] 5 mg/kg i.v. 11.2 μM·h 49.8 μM 17.5 mL/min/kg 1.68 L/kg 3.77 h / /
In Vivo

VNT-101 (1-30 mg/kg, oral administration, twice daily for 5 days) exerts anti-influenza effect in Balb/c mice infected with H1N1 virus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H1N1/PR8 influenza A virus (1000 pfu in inoculum, twice the LD100) was intranasally infected into Balb/c mice to establish a lethal influenza infection model[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: oral administration, twice daily for 5 days
Result: Exerted effective anti-influenza activity in Balb/c mice infected with H1N1 virus.
Ensayo clínico
Peso molecular

456.41

Fòrmula

C21H23F3N2O6
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

COC[C@]1(COC[C@H](O1)COC2=CC=C(C(C=C3C(N)=O)=C(C(F)(F)F)NC3=O)C=C2)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (219.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1910 mL 10.9551 mL 21.9101 mL
5 mM 0.4382 mL 2.1910 mL 4.3820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1910 mL 10.9551 mL 21.9101 mL 54.7753 mL
5 mM 0.4382 mL 2.1910 mL 4.3820 mL 10.9551 mL
10 mM 0.2191 mL 1.0955 mL 2.1910 mL 5.4775 mL
15 mM 0.1461 mL 0.7303 mL 1.4607 mL 3.6517 mL
20 mM 0.1096 mL 0.5478 mL 1.0955 mL 2.7388 mL
25 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1910 mL
30 mM 0.0730 mL 0.3652 mL 0.7303 mL 1.8258 mL
40 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3694 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
60 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9129 mL
80 mM 0.0274 mL 0.1369 mL 0.2739 mL 0.6847 mL
100 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.5478 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

VNT-101 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VNT-1012894060-67-2VNT101VNT 101Influenza Virusinfluenza Aribonucleoproteincellular cytopathic effectNeuraminidaseInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
VNT-101
Cat. No.:
HY-175469
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.