VU590 dihydrochloride

Art. -Nr.: HY-110076: Data Sheet
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VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC₅₀ of 290 nM. VU590 also inhibits Kir7.1, with an IC₅₀ of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney.

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VU590 dihydrochloride Chemische Struktur

CAS. Nr. : 1783987-83-6

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5 mg	Angebot einholen 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Angebot einholen
50 mg	Angebot einholen

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Based on 2 publication(s) in Google Scholar

Other Forms of VU590 dihydrochloride:

VU590 In-stock

2 Publications Citing Use of MCE VU590 dihydrochloride

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung	VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC₅₀ of 290 nM. VU590 also inhibits Kir7.1, with an IC₅₀ of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney^[1]^[2].
IC₅₀ & Target	IC₅₀: 290 nM (Kir1.1), 8 μM (Kir7.1)^[1]
Molekulargewicht	561.46
Formel	C₂₄H₃₄Cl₂N₄O₇
CAS. Nr.	1783987-83-6
SMILES	O=[N+](C1=CC=C(CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)C=C1)[O-].Cl.Cl
Versand	Room temperature in continental US; may vary elsewhere.
Speicherung	Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation	Data Sheet (273 KB) SDS (252 KB) Handling Instructions (2659 KB)
Verweise	[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [Content Brief] [2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. [Content Brief]