1783987-83-6
1783987-83-6
Chemical Structure
VU590 dihydrochloride
- CAS No.: 1783987-83-6
- Formula:C24H34Cl2N4O7
- Molecular Weight:561.46
IUPAC Name: 7,13-bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
InChIKey: FRYYSUBAHIUBNJ-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)C=C1)[O-].Cl.Cl
Biological Activity: VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney[1][2].
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VU590 dihydrochloride | VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney. | |||||||||||||||||||||
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References
- [1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [Content Brief]
- [2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. [Content Brief]
Keywords
