VU590 dihydrochloride
Based on 3 publication(s) in Google Scholar
VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney.
For research use only. We do not sell to patients.
- CAS No.: 1783987-83-6
- Formula: C24H34Cl2N4O7
- Molecular Weight:561.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) VU590 dihydrochloride
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Biological Activity
IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]
Chemical Information
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CAS No. 1783987-83-6
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Molecular Weight 561.46
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Formula C24H34Cl2N4O7
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SMILES
O=[N+](C1=CC=C(CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)C=C1)[O-].Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
The Elongation Factor 1 Alpha Promoter Drives the Functional Expression of Kir2A in Plutella xylostella Cells. [Abstract]2025 Mar 26;26(7):3042. PMID: 40243678 -
Pest Manag Sci
Genetic and pharmacological inhibition of Kir1 impacts mating behavior of the diamondback moth (Plutella xylostella). [Abstract]2025 Aug 22. PMID: 40847487 -
Insect Sci
Genetic and pharmacological inhibition of the Kir2A channel in diamondback moth exhibits ovicidal activity. [Abstract]2026 May 11. PMID: 42116718
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [Content Brief]
[2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU590 dihydrochloride Related Classifications
HY-110076 Related Classifications
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