VU590 dihydrochloride
Based on 3 publication(s) in Google Scholar
VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney.
For research use only. We do not sell to patients.
- CAS No.: 1783987-83-6
- Formula: C24H34Cl2N4O7
- Molecular Weight:561.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) VU590 dihydrochloride
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Biological Activity
Description
IC50 & Target
IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]
Chemical Information
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CAS No. 1783987-83-6
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Molecular Weight 561.46
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Formula C24H34Cl2N4O7
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SMILES
O=[N+](C1=CC=C(CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)C=C1)[O-].Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
The Elongation Factor 1 Alpha Promoter Drives the Functional Expression of Kir2A in Plutella xylostella Cells. [Abstract]2025 Mar 26;26(7):3042. PMID: 40243678 -
Pest Manag Sci
Genetic and pharmacological inhibition of Kir1 impacts mating behavior of the diamondback moth (Plutella xylostella). [Abstract]2025 Aug 22. PMID: 40847487 -
Insect Sci
Genetic and pharmacological inhibition of the Kir2A channel in diamondback moth exhibits ovicidal activity. [Abstract]2026 May 11. PMID: 42116718
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [Content Brief]
[2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU590 dihydrochloride Related Classifications
HY-110076 Related Classifications
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