2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. VU590

VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney.

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VU590 Chemical Structure

VU590 Chemical Structure

CAS No. : 313505-85-0

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Description

VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].

IC50 & Target

IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]
Molecular Weight

488.53

Formula

C24H32N4O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[O-][N+](C1=CC=C(C=C1)CN(CCOCCOCC2)CCOCCN2CC(C=C3)=CC=C3[N+]([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0470 mL 10.2348 mL 20.4696 mL
5 mM 0.4094 mL 2.0470 mL 4.0939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0470 mL 10.2348 mL 20.4696 mL 51.1739 mL
5 mM 0.4094 mL 2.0470 mL 4.0939 mL 10.2348 mL
10 mM 0.2047 mL 1.0235 mL 2.0470 mL 5.1174 mL
15 mM 0.1365 mL 0.6823 mL 1.3646 mL 3.4116 mL
20 mM 0.1023 mL 0.5117 mL 1.0235 mL 2.5587 mL
25 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0470 mL
30 mM 0.0682 mL 0.3412 mL 0.6823 mL 1.7058 mL
40 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
50 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
60 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8529 mL
80 mM 0.0256 mL 0.1279 mL 0.2559 mL 0.6397 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
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VU590 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU590313505-85-0VU 590VU-590Potassium ChannelKcsAPotassium (K+) ChannelRenal outer medullary potassium channel (ROMK)Inward rectifier potassium (Kir)Diuretic targetInhibitorinhibitorinhibit

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