313505-85-0
313505-85-0
Chemical Structure
VU590
- CAS No.: 313505-85-0
- Formula:C24H32N4O7
- Molecular Weight:488.53
IUPAC Name: 7,13-bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane
InChIKey: UKMHVECLTZDSBD-UHFFFAOYSA-N
SMILES: [O-][N+](C1=CC=C(C=C1)CN(CCOCCOCC2)CCOCCN2CC(C=C3)=CC=C3[N+]([O-])=O)=O
Biological Activity: VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU590 | 98.52% | VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney. | ||||||||||||||||||||
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VU590 (Standard) | ≥98% | VU590 (Standard) is the analytical standard of VU590 (HY-108595). This product is intended for research and analytical applications. VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the Kidney. | ||||||||||||||||||||
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References
- [1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [Content Brief]
- [2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346. [Content Brief]
Keywords
