1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Bavisant dihydrochloride

Bavisant dihydrochloride 

Cat. No.: HY-14880A
Handling Instructions

Bavisant Hcl (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.

For research use only. We do not sell to patients.

Bavisant dihydrochloride Chemical Structure

Bavisant dihydrochloride Chemical Structure

CAS No. : 929622-09-3

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Description

Bavisant Hcl (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. IC50 Value: Target: H3 receptor in vitro: Bavisant completed a phase II ADHD trial, but no results have been reported [1]. in vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1 mg/day, 3 mg/day and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo (p=0.161), and hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed [2]. Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. Phase 2

Clinical Trial
Molecular Weight

402.36

Formula

C₁₉H₂₉Cl₂N₃O₂

CAS No.
SMILES

O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4.[H]Cl.[H]Cl

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BavisantHistamine ReceptorInhibitorinhibitorinhibit

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Bavisant dihydrochloride
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HY-14880A
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