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  3. Drug Derivative
  4. DA 1686

DA 1686 is an orally active naphthalene derivative that induces bradycardia and mild hypotension. DA 1686 can be used in the study of arrhythmias.

For research use only. We do not sell to patients.

DA 1686

DA 1686 Chemical Structure

CAS No. : 13071-27-7

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DA 1686 Related Antibodies

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Description

DA 1686 is an orally active naphthalene derivative that induces bradycardia and mild hypotension. DA 1686 can be used in the study of arrhythmias[1].

In Vitro

DA 1686 reduces aconitine-induced tachycardia and responsiveness to increased electrical stimulation in isolated guinea-pig auricles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DA 1686 Related Antibodies
In Vivo

DA 1686 exhibits local anaesthetic activity in in vivo mouse and guinea-pig models[1].
DA 1686 (20 mg/kg; i.v.; slow infusion) protects anaesthetized dogs from Adrenaline (HY-B0447)-induced death during benzol inhalation[1].
DA 1686 protects rats from arrhythmia induced by intravenous administration of 34 μg/kg Aconitine[1].
DA 1686 delays the onset of Ouabain (HY-B1457)-induced arrhythmia, ventricular fibrillation, and cardiac arrest in guinea-pigs[1].
DA 1686 reduces tachycardia induced by 10 days of daily 0.2 mg Thyroxine (HY-18341) administration in rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dog[1]
Dosage: 20 mg/kg
Administration: i.v.; slow infusion
Result: Protected anaesthetized dogs from death induced by rapid intravenous adrenaline administration during benzol inhalation.
Molecular Weight

368.51

Formula

C23H32N2O2
CAS No.
SMILES

N1(CCC(CCN2CCOCC2)C3=CC=CC4=C3C=CC=C4)CCOCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DA 1686 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DA 168613071-27-7DA1686DA-1686Drug DerivativeDrug derivativeanaesthetized dogsguinea-pigstachycardiaratsarrhythmiacardiac arresthypotensionrabbitsventricular fibrillationguinea-pig auriclesInhibitorinhibitorinhibit

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