1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. XE 991 dihydrochloride

XE 991 dihydrochloride 

Cat. No.: HY-108577 Purity: 98.44%
Handling Instructions

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively.

For research use only. We do not sell to patients.

XE 991 dihydrochloride Chemical Structure

XE 991 dihydrochloride Chemical Structure

CAS No. : 122955-13-9

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].

IC50 & Target

IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1]

In Vitro

XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

449.37

Formula

C₂₆H₂₂Cl₂N₂O

CAS No.

122955-13-9

SMILES

O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (15.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2253 mL 11.1267 mL 22.2534 mL
5 mM 0.4451 mL 2.2253 mL 4.4507 mL
10 mM 0.2225 mL 1.1127 mL 2.2253 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.71 mg/mL (1.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.71 mg/mL (1.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.71 mg/mL (1.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

XE 991XE991XE-991Potassium ChannelKcsAInhibitorinhibitorinhibit

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Product Name:
XE 991 dihydrochloride
Cat. No.:
HY-108577
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