1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. XE 991 dihydrochloride

XE 991 dihydrochloride 

Cat. No.: HY-108577
Handling Instructions

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively.

For research use only. We do not sell to patients.

XE 991 dihydrochloride Chemical Structure

XE 991 dihydrochloride Chemical Structure

CAS No. : 122955-13-9

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Description

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].

IC50 & Target

IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1]

In Vitro

XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2].

Molecular Weight

449.37

Formula

C₂₆H₂₂Cl₂N₂O

CAS No.

122955-13-9

SMILES

O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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XE 991 dihydrochloride
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HY-108577
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