XE991

Cat. No.: HY-108577A: FAQs
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XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.

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XE991 Chemical Structure

CAS No. : 122955-42-4

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Other In-stock Forms of XE991:

XE991 dihydrochloride

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XE991 dihydrochloride In-stock

2 Publications Citing Use of MCE XE991

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Description	XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively^[1].
In Vitro	XE 991 dihydrochloride possesses an EC₅₀ of 490 nM for enhancement of [³H]ACh release from rat brain slices, and shows good in vivo potency and duration of action^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. XE991 Related Antibodies
Molecular Weight	376.45
Formula	C₂₆H₂₀N₂O
CAS No.	122955-42-4
SMILES	O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (276 KB) Handling Instructions (2659 KB)
References	[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. [Content Brief] [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XE991122955-42-4XE 991XE-991Potassium ChannelKcsAInhibitorinhibitorinhibit

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XE991

Other Forms of XE991:

XE991 Related Antibodies

2 Publications Citing Use of MCE XE991

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Biological Activity

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