XPhos  (Synonyms: 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl)

XPhos is a dual aryl monophosphine ligand. XPhos is an efficient and stable palladium catalytic ligand. XPhos can be used for amination of aryl sulfonate esters^[1][2].

476.72

C₃₃H₄₉P

564483-18-7

Solid

White to off-white

CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Huang X, et al. Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions. J Am Chem Soc. 2003 Jun 4;125(22):6653-5.  [Content Brief]

  [2]. Kinzel T, et al. A new palladium precatalyst allows for the fast Suzuki-Miyaura coupling reactions of unstable polyfluorophenyl and 2-heteroaryl boronic acids. J Am Chem Soc. 2010 Oct 13;132(40):14073-5.  [Content Brief]