α-Methyl-p-tyrosine

Name: α-Methyl-p-tyrosine
Brand: MedChemExpress
SKU: HY-33549
Rating: 5.0 (2 reviews)

Cat. No.: HY-33549 Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
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α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases.

For research use only. We do not sell to patients.

α-Methyl-p-tyrosine Chemical Structure

CAS No. : 658-48-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of α-Methyl-p-tyrosine:

DL-Metirosine-¹³C,d₃ hydrochloride Get quote
α-Methyl-p-tyrosine (Standard) Get quote

2 Publications Citing Use of MCE α-Methyl-p-tyrosine

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

α-Methyl-p-tyrosine (1 μM, 2 days) can effectively inhibit Latanoprost (HY-B0577)-induced melanogenesis in human uveal melanocytes^[3].
α-Methyl-p-tyrosine (2 g/day, administered for 10 months) can effectively inhibit catecholamine synthesis in pheochromocytoma, exhibiting antitumor activity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-Methyl-p-tyrosine (250 mg/kg, intraperitoneal injection, single dose) can exacerbate the severity and duration of tonic and clonic seizures induced by Pentylenetetrazol in male CFI mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pentylenetetrazol (PTZ)-induced epilepsy CFI strain mouse model (15-25 g)
Dosage:	250 mg/kg
Administration:	Intraperitoneal injection (i.p.), single dose, PTZ administered 8 hours after α-Methyl-p-tyrosine injection
Result:	Increased the severity and duration of seizures, especially enhancing tonic and clonic seizures induced by PTZ.

Molecular Weight

195.22

Formula

C₁₀H₁₃NO₃

CAS No.

658-48-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)(CC1=CC=C(C=C1)O)N)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

0.1 M NaOH : 10 mg/mL (51.22 mM; Need ultrasonic)

H₂O : 1.92 mg/mL (9.84 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1225 mL	25.6124 mL	51.2248 mL
5 mM	1.0245 mL	5.1225 mL	10.2450 mL
10 mM	0.5122 mL	2.5612 mL	5.1225 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 2.5 mg/mL (12.81 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (120 KB) RP-HPLC (215 KB)

Handling Instructions (2659 KB)

References

[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9. [Content Brief]

[2]. Abed WT. Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. Pharmacol Biochem Behav. 1986 Nov;25(5):949-52. [Content Brief]

[3]. Drago F, et al. alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res. 1999 Jan;68(1):85-90. [Content Brief]

[4]. Jones NF, et al. Alpha-methyl-p-tyrosine in the management of phaeochromocytoma. Lancet. 1968 Nov 23;2(7578):1105-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 0.1 M NaOH	1 mM	5.1225 mL	25.6124 mL	51.2248 mL	128.0620 mL
H₂O / 0.1 M NaOH	5 mM	1.0245 mL	5.1225 mL	10.2450 mL	25.6124 mL
0.1 M NaOH	10 mM	0.5122 mL	2.5612 mL	5.1225 mL	12.8062 mL
	15 mM	0.3415 mL	1.7075 mL	3.4150 mL	8.5375 mL
	20 mM	0.2561 mL	1.2806 mL	2.5612 mL	6.4031 mL
	25 mM	0.2049 mL	1.0245 mL	2.0490 mL	5.1225 mL
	30 mM	0.1707 mL	0.8537 mL	1.7075 mL	4.2687 mL
	40 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2015 mL
	50 mM	0.1024 mL	0.5122 mL	1.0245 mL	2.5612 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.