658-48-0
658-48-0
Chemical Structure
Racemetirosine
Synonym(s): α-Methyl-p-tyrosine
- CAS No.: 658-48-0
- Formula:C10H13NO3
- Molecular Weight:195.22
IUPAC Name: 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
InChIKey: NHTGHBARYWONDQ-UHFFFAOYSA-N
SMILES: O=C(C(C)(CC1=CC=C(C=C1)O)N)O
Biological Activity: α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases[1][2][3][4].
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Racemetirosine | 99.41% | α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases. | ||||||||||||||||||||
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Racemetirosine (Standard) | ≥98% | α-Methyl-p-tyrosine (Standard) is the analytical standard of α-Methyl-p-tyrosine. This product is intended for research and analytical applications. α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases. | ||||||||||||||||||||
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DL-Racemetirosine-13C,d3 hydrochloride | DL-Metirosine-13C,d3 (hydrochloride) is deuterium labeled α-Methyl-p-tyrosine. | |||||||||||||||||||||
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References
- [1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9. [Content Brief]
- [2]. Abed WT. Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. Pharmacol Biochem Behav. 1986 Nov;25(5):949-52. [Content Brief]
- [3]. Drago F, et al. alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res. 1999 Jan;68(1):85-90. [Content Brief]
- [4]. Jones NF, et al. Alpha-methyl-p-tyrosine in the management of phaeochromocytoma. Lancet. 1968 Nov 23;2(7578):1105-9. [Content Brief]
