α-Methyl-p-tyrosine
Based on 3 publication(s) in Google Scholar
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 658-48-0
- Formula: C10H13NO3
- Molecular Weight:195.22
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-Methyl-p-tyrosine
More
Biological Activity
α-Methyl-p-tyrosine (1 μM, 2 days) can effectively inhibit Latanoprost (HY-B0577)-induced melanogenesis in human uveal melanocytes[3]. α-Methyl-p-tyrosine (2 g/day, administered for 10 months) can effectively inhibit catecholamine synthesis in pheochromocytoma, exhibiting antitumor activity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Pentylenetetrazol (PTZ)-induced epilepsy CFI strain mouse model (15-25 g)
-
Dosage:250 mg/kg
-
Administration:Intraperitoneal injection (i.p.), single dose, PTZ administered 8 hours after α-Methyl-p-tyrosine injection
-
Result:Increased the severity and duration of seizures, especially enhancing tonic and clonic seizures induced by PTZ.
Chemical Information
-
CAS No. 658-48-0
-
Appearance Solid
-
Molecular Weight 195.22
-
Formula C10H13NO3
-
Color White to off-white
-
SMILES
O=C(C(C)(CC1=CC=C(C=C1)O)N)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Metabolism
Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects against diet-induced obesity by regulating sympathetic activity. [Abstract]2025 Jul:168:156262. PMID: 40204210 -
J Pharmacol Exp Ther
Metabolic characteristics and antidepressant mechanism of cerebroprotein hydrolysate oral liquid via regulating tyrosine hydroxylase and neurotransmitter balance. [Abstract]2025 Dec 8;393(1):103791. PMID: 41475181 -
Solvent & Solubility
0.1 M NaOH : 10 mg/mL (51.22 mM; Need ultrasonic)
H2O : 1.92 mg/mL (9.84 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 2.5 mg/mL (12.81 mM); Suspended solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9. [Content Brief]
[2]. Abed WT. Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. Pharmacol Biochem Behav. 1986 Nov;25(5):949-52. [Content Brief]
[3]. Drago F, et al. alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res. 1999 Jan;68(1):85-90. [Content Brief]
[4]. Jones NF, et al. Alpha-methyl-p-tyrosine in the management of phaeochromocytoma. Lancet. 1968 Nov 23;2(7578):1105-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 0.1 M NaOH | 1 mM | 5.1225 mL | 25.6124 mL | 51.2248 mL | 128.0620 mL |
| 5 mM | 1.0245 mL | 5.1225 mL | 10.2450 mL | 25.6124 mL | |
| 0.1 M NaOH | 10 mM | 0.5122 mL | 2.5612 mL | 5.1225 mL | 12.8062 mL |
| 15 mM | 0.3415 mL | 1.7075 mL | 3.4150 mL | 8.5375 mL | |
| 20 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4031 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0490 mL | 5.1225 mL | |
| 30 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL | |
| 40 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 50 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Methyl-p-tyrosine Related Classifications
HY-33549 Related Classifications
Powered by Bioz