α-Methyl-p-tyrosine

Name: α-Methyl-p-tyrosine
Brand: MedChemExpress
SKU: HY-33549
Rating: 5.0 (2 reviews)

製品番号: HY-33549 純度: 99.41%: Data Sheet SDS COA 取扱説明書
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α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

α-Methyl-p-tyrosine 構造式

CAS 番号 : 658-48-0

容量	価格（税別）	在庫状況	数量
5 mg	$60	在庫あり	Estimated Time of Arrival: December 31
10 mg	$90	在庫あり	Estimated Time of Arrival: December 31
25 mg	$180	在庫あり	Estimated Time of Arrival: December 31
50 mg	$260	在庫あり	Estimated Time of Arrival: December 31
100 mg	$360	在庫あり	Estimated Time of Arrival: December 31
500 mg	$800	在庫あり	Estimated Time of Arrival: December 31
1 g	$1080	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of α-Methyl-p-tyrosine:

DL-Metirosine-¹³C,d₃ hydrochloride お問い合わせ
α-Methyl-p-tyrosine (Standard) お問い合わせ

顧客検証

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•関連タンパク質:

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

α-Methyl-p-tyrosine (1 μM, 2 days) can effectively inhibit Latanoprost (HY-B0577)-induced melanogenesis in human uveal melanocytes^[3].
α-Methyl-p-tyrosine (2 g/day, administered for 10 months) can effectively inhibit catecholamine synthesis in pheochromocytoma, exhibiting antitumor activity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

α-Methyl-p-tyrosine (250 mg/kg, intraperitoneal injection, single dose) can exacerbate the severity and duration of tonic and clonic seizures induced by Pentylenetetrazol in male CFI mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pentylenetetrazol (PTZ)-induced epilepsy CFI strain mouse model (15-25 g)
Dosage:	250 mg/kg
Administration:	Intraperitoneal injection (i.p.), single dose, PTZ administered 8 hours after α-Methyl-p-tyrosine injection
Result:	Increased the severity and duration of seizures, especially enhancing tonic and clonic seizures induced by PTZ.

分子量

195.22

分子式

C₁₀H₁₃NO₃

CAS 番号

658-48-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)(CC1=CC=C(C=C1)O)N)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

0.1 M NaOH : 10 mg/mL (51.22 mM; Need ultrasonic)

H₂O : 1.92 mg/mL (9.84 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1225 mL	25.6124 mL	51.2248 mL
5 mM	1.0245 mL	5.1225 mL	10.2450 mL
10 mM	0.5122 mL	2.5612 mL	5.1225 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 2.5 mg/mL (12.81 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.41%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (247 KB) HNMR (120 KB) RP-HPLC (215 KB)

取扱説明書 (2659 KB)

参考文献

[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9. [Content Brief]

[2]. Abed WT. Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. Pharmacol Biochem Behav. 1986 Nov;25(5):949-52. [Content Brief]

[3]. Drago F, et al. alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res. 1999 Jan;68(1):85-90. [Content Brief]

[4]. Jones NF, et al. Alpha-methyl-p-tyrosine in the management of phaeochromocytoma. Lancet. 1968 Nov 23;2(7578):1105-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 0.1 M NaOH	1 mM	5.1225 mL	25.6124 mL	51.2248 mL	128.0620 mL
H₂O / 0.1 M NaOH	5 mM	1.0245 mL	5.1225 mL	10.2450 mL	25.6124 mL
0.1 M NaOH	10 mM	0.5122 mL	2.5612 mL	5.1225 mL	12.8062 mL
	15 mM	0.3415 mL	1.7075 mL	3.4150 mL	8.5375 mL
	20 mM	0.2561 mL	1.2806 mL	2.5612 mL	6.4031 mL
	25 mM	0.2049 mL	1.0245 mL	2.0490 mL	5.1225 mL
	30 mM	0.1707 mL	0.8537 mL	1.7075 mL	4.2687 mL
	40 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2015 mL
	50 mM	0.1024 mL	0.5122 mL	1.0245 mL	2.5612 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.