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  4. 1-Cyclohexanol

1-Cyclohexanol  (Synonyms: Hydroxycyclohexane; NSC 54711; Naxol; Cyclohexanol)

製品番号: HY-Y1217 純度: 99.94%
COA 取扱説明書 Technical Support

1-Cyclohexanol (Hydroxycyclohexane; NSC 5471) is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

1-Cyclohexanol

1-Cyclohexanol 構造式

CAS 番号 : 108-93-0

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Liquid
25 g $30 在庫あり
50 g $40 在庫あり
100 g $52 在庫あり
500 g $178 在庫あり
1 kg $285 在庫あり

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

Other Forms of 1-Cyclohexanol:

1-Cyclohexanol 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

1-Cyclohexanol (Hydroxycyclohexane; NSC 5471) is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly[1].

体外実験

Cyclohexanol (1000.0 μg/mL; 4 h) is not mutagenic to mouse lymphoma L5178Y cells in vitro, with or without metabolic activation[1].
Cyclohexanol (15000 μg/plate) does not exhibit mutagenic activity in Salmonella typhimurium strains TA98, TA1535, TA1537, and TA1538, with or without metabolic activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Cyclohexanol 関連抗体
体内実験

Cyclohexanol (500-1500 mg/kg; p.o.; single dose) does not induce clastogenic effects in the bone marrow of NMRI mice[1].
Cyclohexanol (159-478 mg/kg/day; inhalation; 6 h/day, 5 days/week; 13-16 weeks) has a no observed adverse effect level (NOAEL) for repeated dose inhalation toxicity in Sprague Dawley rats of 159 mg/kg/day, with treatment-related mortality and clinical signs occurring at 478 mg/kg/day[1].
Cyclohexanol (25 mg/kg/day; p.o.; daily; 40 days) induces reversible male infertility in rabbits by inhibiting spermatogenesis at the spermatocyte and spermatid levels[1].
Cyclohexanol does not induce skin sensitization in guinea pigs in a maximization test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI (male and female)[1]
Dosage: 500 mg/kg; 1000 mg/kg; 1500 mg/kg
Administration: p.o.; single dose
Result: Showed no statistically significant increase in the incidence of micronucleated polychromatic erythrocytes at any tested dose or time point.
Animal Model: Sprague Dawley (male and female)[1]
Dosage: 159 mg/kg/day (equivalent to 150 ppm); 478 mg/kg/day (equivalent to 450 ppm, reduced to 400 ppm after 10 weeks)
Administration: inhalation; 6 h/day, 5 days/week; 13-16 weeks
Result: Showed no treatment-related effects at 159 mg/kg/day across all evaluated endpoints.
Caused treatment-related mortality in male rats on study days 37, 38, and 60, and euthanasia of 1 female rat in extremis on day 17 at 478 mg/kg/day.
Induced immediate post-exposure decreased activity and prostration in both sexes at 478 mg/kg/day.
Animal Model: Sprague Dawley (female)[1]
Dosage: 300 mg/kg/day; 600 mg/kg/day
Administration: p.o.; daily; gestation days 6-15
Result: Showed no treatment-related or toxicologically relevant effects in fetuses at 300 mg/kg/day or 600 mg/kg/day.
Induced treatment-related clinical signs of hypoactivity and/or salivation in 21 out of 24 dams at 600 mg/kg/day, with no such signs at 300 mg/kg/day.
Animal Model: unspecified (male)[1]
Dosage: 25 mg/kg/day
Administration: p.o.; daily; 40 days
Result: Induced degenerative changes in testes (loss of type A spermatogonia, spermatocytes, spermatids, and spermatozoa; morphological changes to spermatids; shrunken Leydig cells) and epididymides (reduced luminal epithelium, scanty stereocilia, spermatozoa-free lumens).
Caused statistically significant reductions in testicular/epididymal RNA, protein, sialic acid, and glycogen, increases in testicular cholesterol, reduced acid phosphatase activity, decreased adrenal ascorbic acid, reduced serum protein, and elevated serum cholesterol, phospholipids, triglycerides, bilirubin, pyruvate transaminase, and alkaline phosphatase.
Reversed all histological and biochemical changes to subnormal levels after a 70-day recovery period.
分子量

100.16

分子式

C6H12O
CAS 番号
Appearance

Liquid (Density: 0.948 g/cm3)

Color

Colorless to light yellow

SMILES

OC1CCCCC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (1996.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.9840 mL 49.9201 mL 99.8403 mL
5 mM 1.9968 mL 9.9840 mL 19.9681 mL
10 mM 0.9984 mL 4.9920 mL 9.9840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (49.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (49.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.94%

COA (246 KB) HNMR (130 KB) GC (189 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.9840 mL 49.9201 mL 99.8403 mL 249.6006 mL
5 mM 1.9968 mL 9.9840 mL 19.9681 mL 49.9201 mL
10 mM 0.9984 mL 4.9920 mL 9.9840 mL 24.9601 mL
15 mM 0.6656 mL 3.3280 mL 6.6560 mL 16.6400 mL
20 mM 0.4992 mL 2.4960 mL 4.9920 mL 12.4800 mL
25 mM 0.3994 mL 1.9968 mL 3.9936 mL 9.9840 mL
30 mM 0.3328 mL 1.6640 mL 3.3280 mL 8.3200 mL
40 mM 0.2496 mL 1.2480 mL 2.4960 mL 6.2400 mL
50 mM 0.1997 mL 0.9984 mL 1.9968 mL 4.9920 mL
60 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
80 mM 0.1248 mL 0.6240 mL 1.2480 mL 3.1200 mL
100 mM 0.0998 mL 0.4992 mL 0.9984 mL 2.4960 mL
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1-Cyclohexanol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Cyclohexanol108-93-0Hydroxycyclohexane NSC 54711 Naxol CyclohexanolNSC54711NSC 54711NSC-54711Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantsblack currantsSprague Dawley ratsmouse lymphoma L5178Y cellsguinea pigsSalmonella typhimuriumrabbitsacerolabeansNMRI micechestnutInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-Y1217
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