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  4. 2,3-Diaminonaphthalene

2,3-Diaminonaphthalene is a fluorescent reagent used to detect selenium and nitric oxide (NO). 2,3-Diaminonaphthalene binds to selenium to form pyrazolene selenol, with excitation/emission maxima at 365 nm and 525 nm, respectively. 2,3-Diaminonaphthalene binds to NO2− to form the fluorescent product, 1-(H)-napthotriazole, with excitation/emission maxima at 360 nm and 440 nm, respectively.

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2,3-Diaminonaphthalene

2,3-Diaminonaphthalene Chemische Struktur

CAS. Nr. : 771-97-1

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10 mM * 1 mL in DMSO
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2,3-Diaminonaphthalene Related Antibodies

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Beschreibung

2,3-Diaminonaphthalene is a fluorescent reagent used to detect selenium and nitric oxide (NO). 2,3-Diaminonaphthalene binds to selenium to form pyrazolene selenol, with excitation/emission maxima at 365 nm and 525 nm, respectively. 2,3-Diaminonaphthalene binds to NO2− to form the fluorescent product, 1-(H)-napthotriazole, with excitation/emission maxima at 360 nm and 440 nm, respectively[1][2].

In Vitro

Poly(2,3-diaminonaphthalene) microspheres as a novel quencher for fluorescence-enhanced nucleic acid detection[1].
2,3-Diaminonaphthalene (DAN) is possibly a carcinogenic reagent[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,3-Diaminonaphthalene Related Antibodies
Molekulargewicht

158.20

Formel

C10H10N2
CAS. Nr.
Appearance

Solid

Color

Light yellow to light brown

Emission (Em)

415
Excitation (Ex)

365
SMILES

NC1=C(N)C=C2C=CC=CC2=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

RT, protect from light

In solvent -80°C 1 year
-20°C 6 months
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (632.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3211 mL 31.6056 mL 63.2111 mL
5 mM 1.2642 mL 6.3211 mL 12.6422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molaritätsrechner

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.00%

SDS (557 KB)

COA (249 KB) HNMR (243 KB) RP-HPLC (258 KB) MS (229 KB)

Handling Instructions (2659 KB)
Verweise
Kinase-Assay
[3]

Various concentrations of each drug are incubated for 60 min at 37°C in OS-mL reaction volumes containing PBS (pH 7.4), 200 μM 2,3-Diaminonaphthalene (DAN) and 40 μM Sp/NO. Spermine/NO will spontaneously decompose at pH7.4 to produce 2 mol of NO and 1 mol of spermine with a half-life of 39 min at 37°C. Following the incubation period, 2.5 mL of 10 mM NaOH is added to each tube to stop the reaction. The NO-dependent N-nitrosation of 2,3-Diaminonaphthalene to yield its highly fluorescent N-nitrosated derivative, 2,3-naphthotriazole, is quantified by measuring the fluorescence of each sample using an excitation wavelength of 375 nm and an emission wavelength of 450nm. The concentration of Triazole is determined using standards of the pure 2,3-naphthotriazole[3].

MCE hat die Genauigkeit dieser Methoden nicht unabhängig bestätigt. Sie dienen nur als Referenz.
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3211 mL 31.6056 mL 63.2111 mL 158.0278 mL
5 mM 1.2642 mL 6.3211 mL 12.6422 mL 31.6056 mL
10 mM 0.6321 mL 3.1606 mL 6.3211 mL 15.8028 mL
15 mM 0.4214 mL 2.1070 mL 4.2141 mL 10.5352 mL
20 mM 0.3161 mL 1.5803 mL 3.1606 mL 7.9014 mL
25 mM 0.2528 mL 1.2642 mL 2.5284 mL 6.3211 mL
30 mM 0.2107 mL 1.0535 mL 2.1070 mL 5.2676 mL
40 mM 0.1580 mL 0.7901 mL 1.5803 mL 3.9507 mL
50 mM 0.1264 mL 0.6321 mL 1.2642 mL 3.1606 mL
60 mM 0.1054 mL 0.5268 mL 1.0535 mL 2.6338 mL
80 mM 0.0790 mL 0.3951 mL 0.7901 mL 1.9753 mL
100 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.5803 mL
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2,3-Diaminonaphthalene Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,3-Diaminonaphthalene771-97-1Fluorescent DyeInhibitorinhibitorinhibit

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