2,2'-Bipyridine

Name: 2,2'-Bipyridine
Brand: MedChemExpress
SKU: HY-D0020
Rating: 4.5 (1 reviews)

Cat. No.: HY-D0020 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
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2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.

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CAS No. : 366-18-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	견적 받기

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of 2,2'-Bipyridine:

2,2′-Bipyridine-d₈ In-stock
2,2'-Bipyridine (Standard) In-stock

1 Publications Citing Use of MCE 2,2'-Bipyridine

•J Photochem Photobiol B. 2024 Aug 30:259:113023. [Abstract]

Microbiological Assay

: 2,2'-Bipyridine purchased from MedChemExpress. Usage Cited in: J Photochem Photobiol B. 2024 Aug 30:259:113023. [Abstract]; Modulation of PAO1 sensitivity to 405 nm aBL in BHI medium with or without FeCl₃ supplementation in the presence of the iron chelator 2,2'-Bipyridine (BIP) (500 μM).

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>20 μM Compound: 2,2' bipy	Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines	[PMID: 11931621]
A2780	IC₅₀	44.8 μM Compound: 2,2' bipy	Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines	[PMID: 11931621]
CCRF-CEM	IC₅₀	51.9 μM Compound: 2,2' bipy	Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines	[PMID: 11931621]
CCRF-CEM	IC₅₀	61.7 μM Compound: 2,2' bipy	Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines	[PMID: 11931621]
COS-7	EC₅₀	19 μM Compound: Bip	Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	EC₅₀	34 μM Compound: Bip	Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	EC₅₀	42 μM Compound: Bip	Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis	[PMID: 22957890]
COS-7	IC₅₀	126 μM Compound: Bip	Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs	[PMID: 22957890]
COS-7	IC₅₀	84 μM Compound: Bip	Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs	[PMID: 22957890]
HUVEC	EC₅₀	10 μM Compound: 2,2'-bipyridine	Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay	[PMID: 23634668]
SK-OV-3	IC₅₀	41.3 μM Compound: 2,2' bipy	Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines	[PMID: 11931621]

In Vivo

2,2'-Bipyridine (40 mg/kg; s.c.; once) produces an initial hyperglycemia (an increase of 53.8 mg/100 mL at 2 hours) followed by a transient hypoglycemicphase at 24 hours and does not produce permanent diabetes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Holtzman rats (6-8 weeks old)^[2].
Dosage:	40 mg/kg
Administration:	Subcutaneous injection; once.
Result:	Showed hyperglycemic activity.

분자량

156.19

화학식

C₁₀H₈N₂

CAS No.

366-18-7

Appearance

Solid

Color

White to light yellow

SMILES

C1(C2=NC=CC=C2)=NC=CC=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 100 mg/mL (640.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4025 mL	32.0123 mL	64.0246 mL
5 mM	1.2805 mL	6.4025 mL	12.8049 mL
10 mM	0.6402 mL	3.2012 mL	6.4025 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.95%

Select Batch:

Data Sheet (275 KB) SDS (480 KB)

COA (250 KB) HNMR (228 KB) RP-HPLC (248 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468. [Content Brief]

[2]. Kenny A D, et al. The hyperglycemic activity of 2, 2'-bipyridine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 135(3): 317-322.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.4025 mL	32.0123 mL	64.0246 mL	160.0615 mL
	5 mM	1.2805 mL	6.4025 mL	12.8049 mL	32.0123 mL
	10 mM	0.6402 mL	3.2012 mL	6.4025 mL	16.0061 mL
	15 mM	0.4268 mL	2.1342 mL	4.2683 mL	10.6708 mL
	20 mM	0.3201 mL	1.6006 mL	3.2012 mL	8.0031 mL
	25 mM	0.2561 mL	1.2805 mL	2.5610 mL	6.4025 mL
	30 mM	0.2134 mL	1.0671 mL	2.1342 mL	5.3354 mL
	40 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0015 mL
	50 mM	0.1280 mL	0.6402 mL	1.2805 mL	3.2012 mL
	60 mM	0.1067 mL	0.5335 mL	1.0671 mL	2.6677 mL
	80 mM	0.0800 mL	0.4002 mL	0.8003 mL	2.0008 mL
	100 mM	0.0640 mL	0.3201 mL	0.6402 mL	1.6006 mL

2,2'-Bipyridine Related Classifications

Infection Endocrinology

Others
MOFs

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,2'-Bipyridine366-18-7MOFsMetal-Organic FrameworksmolecularscaffoldcaerulomycinscollismycinschelatingligandshyperglycemicInhibitorinhibitorinhibit

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2,2'-Bipyridine

고객리뷰

Other Forms of 2,2'-Bipyridine:

2,2'-Bipyridine Related Antibodies

1 Publications Citing Use of MCE 2,2'-Bipyridine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

2,2'-Bipyridine Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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