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  4. 2,2'-Bipyridine

2,2'-Bipyridine  (Synonyms: 2,2′-ビピリジル)

製品番号: HY-D0020 純度: 99.95%
COA 取扱説明書 Technical Support

2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.

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CAS 番号 : 366-18-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $48 在庫あり
5 g $72 在庫あり
10 g $87 在庫あり
50 g   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of 2,2'-Bipyridine:

2,2'-Bipyridine 関連抗体

Top Publications Citing Use of Products

    2,2'-Bipyridine purchased from MedChemExpress. Usage Cited in: J Photochem Photobiol B. 2024 Aug 30:259:113023.  [Abstract]

    Modulation of PAO1 sensitivity to 405 nm aBL in BHI medium with or without FeCl3 supplementation in the presence of the iron chelator 2,2'-Bipyridine (BIP) (500 μM).

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    製品説明

    2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    COS-7 IC50
    126 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    A2780 IC50
    44.8 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    		[PMID: 11931621]
    A2780 IC50
    44.8 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    		[PMID: 11931621]
    COS-7 EC50
    19 3
    Compound: Bip
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    A2780 IC50
    >20 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    		[PMID: 11931621]
    A2780 IC50
    > 20 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    		[PMID: 11931621]
    COS-7 EC50
    34 3
    Compound: Bip
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    CCRF-CEM IC50
    51.9 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    		[PMID: 11931621]
    CCRF-CEM IC50
    61.7 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    		[PMID: 11931621]
    COS-7 EC50
    42 3
    Compound: Bip
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    CCRF-CEM IC50
    61.7 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    		[PMID: 11931621]
    CCRF-CEM IC50
    51.9 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    		[PMID: 11931621]
    COS-7 IC50
    84 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    COS-7 EC50
    19 3
    Compound: Bip
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    34 3
    Compound: Bip
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    HUVEC EC50
    10 3
    Compound: 2,2'-bipyridine
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    		[PMID: 23634668]
    COS-7 EC50
    19 3
    Compound: Bip
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    34 3
    Compound: Bip
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    42 3
    Compound: Bip
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    42 3
    Compound: Bip
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 IC50
    126 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    COS-7 IC50
    126 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    COS-7 IC50
    84 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    COS-7 IC50
    84 3
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    HUVEC EC50
    10 3
    Compound: 2,2'-bipyridine
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    		[PMID: 23634668]
    SK-OV-3 IC50
    41.3 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    		[PMID: 11931621]
    HUVEC EC50
    10 3
    Compound: 2,2'-bipyridine
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    		[PMID: 23634668]
    SK-OV-3 IC50
    41.3 3
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    		[PMID: 11931621]
    体内実験

    2,2'-Bipyridine (40 mg/kg; s.c.; once) produces an initial hyperglycemia (an increase of 53.8 mg/100 mL at 2 hours) followed by a transient hypoglycemicphase at 24 hours and does not produce permanent diabetes[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Holtzman rats (6-8 weeks old)[2].
    Dosage: 40 mg/kg
    Administration: Subcutaneous injection; once.
    Result: Showed hyperglycemic activity.
    分子量

    156.19

    分子式

    C10H8N2
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    C1(C2=NC=CC=C2)=NC=CC=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at room temperature 3 years

    *In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (640.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.4025 mL 32.0123 mL 64.0246 mL
    5 mM 1.2805 mL 6.4025 mL 12.8049 mL
    10 mM 0.6402 mL 3.2012 mL 6.4025 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.95%

    COA (250 KB) HNMR (228 KB) RP-HPLC (248 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 6.4025 mL 32.0123 mL 64.0246 mL 160.0615 mL
    5 mM 1.2805 mL 6.4025 mL 12.8049 mL 32.0123 mL
    10 mM 0.6402 mL 3.2012 mL 6.4025 mL 16.0061 mL
    15 mM 0.4268 mL 2.1342 mL 4.2683 mL 10.6708 mL
    20 mM 0.3201 mL 1.6006 mL 3.2012 mL 8.0031 mL
    25 mM 0.2561 mL 1.2805 mL 2.5610 mL 6.4025 mL
    30 mM 0.2134 mL 1.0671 mL 2.1342 mL 5.3354 mL
    40 mM 0.1601 mL 0.8003 mL 1.6006 mL 4.0015 mL
    50 mM 0.1280 mL 0.6402 mL 1.2805 mL 3.2012 mL
    60 mM 0.1067 mL 0.5335 mL 1.0671 mL 2.6677 mL
    80 mM 0.0800 mL 0.4002 mL 0.8003 mL 2.0008 mL
    100 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6006 mL
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    2,2'-Bipyridine Related Classifications

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2,2'-Bipyridine366-18-7MOFsMetal-Organic FrameworksmolecularscaffoldcaerulomycinscollismycinschelatingligandshyperglycemicInhibitorinhibitorinhibit

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    製品名:
    2,2'-Bipyridine
    製品番号:
    HY-D0020
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